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Merck

E0251

Sigma-Aldrich

Estrone 3-sulfate sodium salt

synthetic (organic), ≥98% (TLC), Inactive estrogen, powder

Synonym(s):

1,3,5(10)-Estratrien-17-one 3-sulfate

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About This Item

Linear Formula:
C18H21O5SNa
CAS Number:
438-67-5
Molecular Weight:
372.41
MDL number:
MFCD00070035
UNSPSC Code:
12352202
PubChem Substance ID:
24894364
NACRES:
NA.77

Key Documents

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Product Name

Estrone 3-sulfate sodium salt, contains ~35% Tris as stabilizer

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

Assay

≥98% (TLC)

form

powder

contains

~35% Tris as stabilizer

technique(s)

inhibition assay: suitable

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H22O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1

InChI key

GQZNDBBLTDOIBE-DLEHHZMWSA-N

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Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Package size based on steroid content

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
086M4083V
085M4170V
099M4044V
13181143
088M4146V

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E S M Silva et al.
Theriogenology, 86(7), 1749-1756 (2016-08-09)
The present study evaluated the influence of different regimens of estradiol benzoate (EB) treatments followed by a single dose of long-acting progesterone (LA P4) on plasma estrogen and P4 concentrations in noncyclic mares prepared as embryo recipients. Twenty-one anestrous mares
Christopher A Pearl et al.
Domestic animal endocrinology, 33(4), 451-459 (2006-10-13)
The steroid hormone regulation of the epididymis in a high estrogen producing animal like the boar is not currently understood. To test the hypothesis that the boar epididymis is an estrogen and androgen responsive tissue, the presence of estrogen and
Takashi Nozawa et al.
Pharmaceutical research, 22(10), 1634-1641 (2005-09-24)
The aim of the study is to suppress the progress of estrogen-dependent breast cancer by inhibiting the membrane transporter, which mediates the internalization of estrone-3-sulfate as estrogen precursor in the cancer cells. The uptake of estrone-3-sulfate by estrogen-dependent breast cancer
Maria Karlgren et al.
Journal of medicinal chemistry, 55(10), 4740-4763 (2012-05-01)
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models
Anna Koenen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 774-780 (2012-09-18)
Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. However, it is unclear whether OATP2B1
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