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E006

β-Carboline-3-carboxylic acid N-methylamide

Name: &#946;-Carboline-3-carboxylic acid N-methylamide
Brand: SIGMA

Benzodiazepine receptor inverse agonist, solid

Synonym(s):

β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₁N₃O

CAS Number:

78538-74-6

Molecular Weight:

225.25

UNSPSC Code:

12352106

PubChem Substance ID:

24278181

NACRES:

NA.77

MDL number:

MFCD00055075

Form:

solid

Quality level:

100

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Properties

Product Name

β-Carboline-3-carboxylic acid N-methylamide,

form

solid

Quality Level

100

color

light tan

solubility

DMSO: >10 mg/mL, H₂O: insoluble

SMILES string

CNC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)

InChI key

QMCOPDWHWYSJSA-UHFFFAOYSA-N

Gene Information

human ... BZRAP1(9256)

Description

Biochem/physiol Actions

Benzodiazepine inverse receptor agonist; potent anxiogenic agent.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Disclaimer

Solutions may be stored for several days at 4 °C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

신경과학을 위한 생체 활성 저분자

Renewal and spontaneous recovery, but not latent inhibition, are mediated by gamma-aminobutyric acid in appetitive conditioning.

Andrew R Delamater et al.

Journal of experimental psychology. Animal behavior processes, 35(2), 224-237 (2009-04-15)

Previous research has reported a role for the neurotransmitter gamma-aminobutyric acid (GABA) in the extinction and renewal of conditioned fear. Here, the authors examine whether GABA is involved in the acquisition, extinction, renewal, spontaneous recovery, and latent inhibition of appetitive

Analysis of vigilant scanning behavior in mice using two-point digital video tracking.

Kwok Ho C Choy et al.

Psychopharmacology, 221(4), 649-657 (2011-12-24)

Vigilant scanning of the environment is a major risk assessment activity in many species. However, due to difficulties in its manual scoring, scanning has rarely been quantified in laboratory rodent studies. We developed a novel method for automated measurement of

The effects of FG 7142 on sensory-specific satiety in rats.

Sarah I Martire et al.

Behavioural brain research, 209(1), 131-136 (2010-02-02)

Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested

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Global Trade Item Number

SKU	GTIN
E006-100MG	04061832556413
E006-500MG	04061832556420