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D8555

N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide

Name: N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
Brand: SIGMA

Synonym(s):

FGIN-1-27

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₃₇FN₂O

CAS Number:

142720-24-9

Molecular Weight:

436.60

NACRES:

NA.77

PubChem Substance ID:

24278393

UNSPSC Code:

12352200

MDL number:

MFCD00467704

Form:

powder

Quality level:

200

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Properties

form

powder

Quality Level

200

solubility

methanol: 50 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c3ccc(F)cc3

InChI

1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3

InChI key

VUWXAQFLTSBUDB-UHFFFAOYSA-N

Gene Information

human ... BZRAP1(9256)
rat ... Tspo(24230)

Description

Biochem/physiol Actions

High affinity ligand for glial mitochondrial benzodiazepine receptors; stimulates neurosteroid biosynthesis; does not bind GABA_A receptors

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.

A P Sutter et al.

British journal of cancer, 89(3), 564-572 (2003-07-31)

Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce apoptosis and cell cycle arrest in oesophageal cancer cells. However, the underlying mechanisms are still unknown. Here, we investigated the transcriptional alterations and activation of protein kinases in

The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells.

Antonio F Santidrián et al.

Haematologica, 92(12), 1631-1638 (2007-12-07)

The potential anticancer agent 1-(2-chlorophenyl-N-methylpropyl)-3-isoquinolinecarboxamide (PK11195), a translocator protein (18KDa) (TSPO) ligand, facilitates the induction of cell death by a variety of cytotoxic and chemotherapeutic agents. Primary chronic lymphocytic leukemia (CLL) cells overexpress TSPO. The aim of this study was

Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.

Cheryl A Frye et al.

Reproduction (Cambridge, England), 137(1), 119-128 (2008-09-27)

The progesterone metabolite and neurosteroid, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), has actions in the midbrain ventral tegmental area (VTA) to modulate lordosis, but its effects on other reproductively relevant behaviors are not well understood. Effects on exploration, anxiety, and social behavior resulting from

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Global Trade Item Number

SKU	GTIN
D8555-5MG	04061832556406
D8555-25MG	04061832556390