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Merck

34851

Sigma-Aldrich

Acetonitrile

≥99.9%, gradient grade, suitable for HPLC

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
Beilstein:
741857
EC Number:
200-835-2
MDL number:
MFCD00001878
UNSPSC Code:
41116105
eCl@ss:
39031501
PubChem Substance ID:
329755061
NACRES:
NA.03
Grade:
gradient grade
Assay:
≥99.9%
Technique(s):
HPLC: suitable
Application(s):
food and beverages
Bp:
81-82 °C (lit.)
Vapor pressure:
72.8 mmHg ( 20 °C)

Key Documents

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Product Name

Acetonitrile, suitable for HPLC, gradient grade, ≥99.9%

grade

gradient grade

Quality Level

100

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

Assay

≥99.9%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

baseline drift measuring range

≤15 mAU (210 nm)

technique(s)

HPLC: suitable

impurities

≤0.0002% free alkali (as NH3)
≤0.0005% non-volatile matter
≤0.001% free acid (as CH3COOH)
≤0.02% water (Karl Fischer)
≤0.5 ppb fluorescence (quinine) at 365 nm
≤1 ppb fluorescence (quinine) at 254 nm

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

density

0.786 g/mL at 25 °C (lit.)

HPLC-gradient

≤0.5 mAU at 254 nm
≤3 mAU at 210 nm

UV absorption

λ: 195 nm Amax: ≤0.12
λ: 200 nm Amax: ≤0.032
λ: 230 nm Amax: ≤0.0044
λ: 235 nm Amax: ≤0.0044
λ: 250 nm Amax: ≤0.0044
λ: 400 nm Amax: ≤0.0044

application(s)

food and beverages

format

neat

storage temp.

room temp

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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General description

Acetonitrile (MeCN) is widely employed as a solvent in various studies and has high dielectric constant (37.5). Various purification procedures to obtain different grades of acetonitrile for use in different studies (polarography, spectroscopy, etc.) have been reported by many researchers.

Application

Acetonitrile (MeCN) may be used as an extraction solvent during the quantification of pesticide residues in fruits and vegetables.

Packaging

View returnable container options.

Preparation Note

Product filtered through a 0.2 μm filter

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Important notice
  • The article number 34851-4X2.5L will be discontinued. Please order the single bottle 34851-2.5L which is physically identical with the same exact specifications.
  • The article number 34851-6X1L will be discontinued. Please order the single bottle 34851-1L which is physically identical with the same exact specifications.
Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
STBL1637
STBL1380
STBL1099
STBL1098
STBL0867

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Purification of acetonitrile.
Walter M and Ramaley L.
Analytical Chemistry, 45(1), 165-166 (1973)
Michelangelo Anastassiades et al.
Journal of AOAC International, 86(2), 412-431 (2003-05-02)
A simple, fast, and inexpensive method for the determination of pesticide residues in fruits and vegetables is introduced. The procedure involves initial single-phase extraction of 10 g sample with 10 mL acetonitrile, followed by liquid-liquid partitioning formed by addition of
Timo Glatter et al.
Molecular systems biology, 5, 237-237 (2009-01-22)
Protein complexes represent major functional units for the execution of biological processes. Systematic affinity purification coupled with mass spectrometry (AP-MS) yielded a wealth of information on the compendium of protein complexes expressed in Saccharomyces cerevisiae. However, global AP-MS analysis of
Elke H J Krekels et al.
Clinical pharmacokinetics, 53(6), 553-563 (2014-02-06)
From a previously validated paediatric population pharmacokinetic model, it was derived that non-linear morphine maintenance doses of 5 μg/kg(1.5)/h, with a 50 % dose reduction in neonates with a postnatal age (PNA) <10 days, yield similar morphine and metabolite concentrations
Divya Subramonian et al.
Journal of proteome research, 13(9), 3905-3918 (2014-07-30)
SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is
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