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186562

Tetrahydrofuran

Name: Tetrahydrofuran
Brand: SIAL

≥99.9%, anhydrous, contains 250 ppm BHT as inhibitor

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):

C₄H₈O

CAS Number:

109-99-9

Molecular Weight:

72.11

NACRES:

NA.21

PubChem Substance ID:

57647757

UNSPSC Code:

12191501

EC Number:

203-726-8

MDL number:

MFCD00005356

Beilstein/REAXYS Number:

102391

Assay:

≥99.9%

Grade:

anhydrous

Bp:

65-67 °C (lit.)

Vapor pressure:

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

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Properties

Product Name

Tetrahydrofuran, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

grade

anhydrous

Quality Level

200

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

610 °F

contains

250 ppm BHT as inhibitor

expl. lim.

1.8-11.8 %

impurities

≤0.005% peroxides (as H₂O₂), <0.002% water (All units except 100 mL), <0.005% water (100 mL pkg)

refractive index

n20/D 1.407 (lit.)

pH

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

H₂O: soluble

density

0.889 g/mL at 25 °C (lit.)

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms double hydrate with hydrogen sulfide, crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

Application

Dry tetrahydrofuran (THF) has been used in the synthesis of dichloro{bis[1,1′,1′′-(phosphinetriyl)tripiperidine]}palladium [(P(NC₅H₁₀)₃)₂Pd(Cl)₂], which is widely used in the Heck reaction as a catalyst. It has been employed in the reaction medium of the Heck cross-coupling reaction of various aryl bromides and olefins.

Packaging

View returnable container options.

Other Notes

Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (414247) and Cyclopentyl methyl ether (675970)

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signalword

Danger

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

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Articles

Solvent Miscibility Table

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

용매 혼용성 표

물질이 용해되어 균일한 용액을 형성하면 서로 섞일 수 있다고 합니다. 일반적인 실험용 용매에 대한 혼용성 표를 북마크하거나 다운로드하세요.

Solvent Stabilizer Systems

A description of stabilizer systems for solvents including esters, ethyl ester, tetrahydrofuran, chlorinated solvents, chloroform and dichloromethane.

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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro {bis [1, 1', 1''-(phosphinetriyl) tripiperidine]} palladium Under Mild Reaction Conditions.

Oberholzer M and Frech CM

Journal of Visualized Experiments, 85, e51444-e51444 (2014)

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Pharmacological research, 117, 67-74 (2016-12-23)

A controversial relationship between sigma-2 and progesterone receptor membrane component 1 (PGRMC1) proteins, both representing promising targets for the therapy and diagnosis of tumors, exists since 2011, when the sigma-2 receptor was reported to be identical to PGRMC1. Because a

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Global Trade Item Number

SKU	GTIN
186562-100ML	04061838758217
186562-200L-AM	04061838161154
186562-200L-P1	04061838151445
186562-200L-P2	04061838225917
186562-2L	04061837531378
186562-400L-P1	04061838151476
186562-4X2L	04061838758224
186562-6X1L	04061838758231
186562-IL-10L-BK	04061838689917
186562-12X100ML	04061837531354
186562-18L	04061838151421
186562-1L	04061837531361
186562-200L-C01	04061838151438
186562-208L	04061838225924
186562-250ML	04061837535611
186562-PS-200LP1NB	04065267793078
186562-PZ	04061823900270