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MAB3291

Anti-HRAS Antibody

CHEMICON®, mouse monoclonal, 7D7.2

Synonym(s):

Anti-C-BAS/HAS, Anti-C-H-RAS, Anti-C-HA-RAS1, Anti-CTLO, Anti-H-RASIDX, Anti-HAMSV, Anti-HRAS1, Anti-RASH1, Anti-p21ras

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
7D7.2, monoclonal
Species reactivity:
rat, mouse, human
Application:
ELISA, WB
Citations:
4
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Product Name

Anti-H-Ras Antibody, clone 7D7.2, clone 7D7.2, Chemicon®, from mouse

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

7D7.2, monoclonal

species reactivity

rat, mouse, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable, western blot: suitable

isotype

IgG2b

NCBI accession no.

NM_005343.2, NM_176795.2

UniProt accession no.

P01112

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... HRAS(3265)

Immunogen

Full-length recombinant human H-Ras - GST fusion protein

Application

Research Category
Signaling
Research Sub Category
MAP Kinases
This Anti-H-Ras Antibody, clone 7D7.2 is validated for use in ELISA, WB for the detection of H-Ras.
Western blot

ELISA

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Recognizes H-Ras (the oncogene of Harvey murine sarcoma virus). Approximate molecular weight of 21 kDa.

Physical form

0.02M phosphate buffer, 0.25M NaCl, pH 7.6, 0.1% sodium azide
Format: Purified

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months.

WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

12 - Non Combustible Liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Sasaki, AT; Carracedo, A; Locasale, JW; Anastasiou, D; Takeuchi, K; Kahoud, ER; Haviv et al.
Science Signaling null
Ho-June Lee et al.
Molecular cancer therapeutics, 16(4), 694-704 (2017-02-01)
Cancer cell line profiling to identify previously unrecognized kinase dependencies revealed a novel nonmutational dependency on the DNA damage response checkpoint kinase Chk1. Although Chk1 is a promising therapeutic target in p53-deficient cancers, we found that Ras-MEK signaling engages Chk1
Candida Zuchegna et al.
Redox report : communications in free radical research, 27(1), 150-157 (2022-07-14)
Although the protooncogenes small GTPases Ras are redox-sensitive proteins, how they are regulated by redox signaling in the central nervous system (CNS) is still poorly understood. Alteration in redox-sensitive targets by redox signaling may have myriad effects on Ras stability

Global Trade Item Number

SKUGTIN
MAB329104053252317897