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Merck

999986O

Avanti

4ME 16:0 Diether DG

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-di-O-phytanyl-sn-glycerol

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About This Item

Empirical Formula (Hill Notation):
C43H88O3
CAS Number:
99341-19-2
Molecular Weight:
653.16
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

4ME 16:0 Diether DG, Avanti Research™ - A Croda Brand 999986O

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 200 mg (999986O-200mg)
pkg of 1 × 5 mg (999986O-5mg)
pkg of 1 × 50 mg (999986O-50mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 999986O

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](CO)(OCCC(C)CCCC(C)CCCC(C)CCCC(C)C)COCCC(C)CCCC(C)CCCC(C)CCCC(C)C

InChI

1S/C43H88O3/c1-35(2)17-11-19-37(5)21-13-23-39(7)25-15-27-41(9)29-31-45-34-43(33-44)46-32-30-42(10)28-16-26-40(8)24-14-22-38(6)20-12-18-36(3)4/h35-44H,11-34H2,1-10H3/t37?,38?,39?,40?,41?,42?,43-/m0/s1

InChI key

ISDBCJSGCHUHFI-PKIBUDCSSA-N

General description

4ME 16:0 Diether DG or 1,2-di-O-phytanyl-sn-glycerol is an archaeal lipid having two phytane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds. It is present as a component of the cell membrane in methanogen microorganisms.

Application

4ME 16:0 Diether DG or 1,2-di-O-phytanyl-sn-glycerol is suitable for use as an internal standard in:
  • the liquid chromatography mass spectrometric (LC–MS) analysis of lipids by multiple reaction monitoring (MRM) transitions
  • high performance liquid chromatography (HPLC) to quantify diacylglycerol (DAG/DG)
  • tandem mass spectrometric (MS/MS) analysis to quantify DAG

Biochem/physiol Actions

Ether linked lipids are antioxidant and essential for cell differentiation and cellular signaling.

Packaging

20 mL Clear Glass Screw Cap Vial (999986O-200mg)
5 mL Clear Glass Sealed Ampule (999986O-50mg)
5 mL Clear Glass Sealed Ampule (999986O-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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A new granulation method for compressed tablets [proceedings].
M H Rubinstein
The Journal of pharmacy and pharmacology, 28 Suppl, 67P-67P (1976-12-01)
Analytical characterization of plasma membrane-derived vesicles produced via osmotic and chemical vesiculation
Sarabipour S, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(7), 1591-1598 (2015)
Xu Si et al.
Molecular nutrition & food research, 62(3) (2017-11-28)
A recent study revealed that the accumulation of gut microbiota-produced acetate (GMPA) led to insulin over-secretion and obesity symptom. To further develop this scientific point, the effect of resistant starch (RS) or exogenous acetate carried by RS (RSA) in the
S Görs et al.
Journal of dairy science, 99(11), 9313-9318 (2016-10-21)
Archaeol (1,2-di-O-phytanyl-sn-glycerol) is a cell membrane lipid component of methanogens that has the potential to be used as a biomarker for methane production in ruminants. However, its analysis via gas chromatography-mass spectrometry (GC-MS) is challenging because of its molecular size
Benjamin T Bikman et al.
The Journal of biological chemistry, 287(21), 17426-17437 (2012-04-05)
Fenretinide is a synthetic retinoid that is being tested in clinical trials for the treatment of breast cancer and insulin resistance, but its mechanism of action has been elusive. Recent in vitro data indicate that fenretinide inhibits dihydroceramide desaturase, an
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