860637P
Avanti
Galactosyl(β) Sphingosine-d5
Avanti Research™ - A Croda Brand
Synonym(s):
D-galactosyl-β1-1′-D-erythro-sphingosine-d5
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About This Item
Empirical Formula (Hill Notation):
C24H42D5NO7
CAS Number:
Molecular Weight:
466.66
UNSPSC Code:
12352211
NACRES:
NA.12
Product Name
Galactosyl(β) Sphingosine-d5, Avanti Research™ - A Croda Brand 860637P, powder
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860637P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860637P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@](/C=C/CCCCCCCCCCCC([2H])(C([2H])([2H])[2H])[2H])(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
InChI key
HHJTWTPUPVQKNA-LTNFHSIGSA-N
Application
Galactosyl(β) Sphingosine-d5 has been used as an internal standard for the quantification of galactosylsphingosine, in the extracts from the mouse cerebellum by liquid chromatography-tandem mass spectrometry.
Biochem/physiol Actions
Galactosylsphingosine, also known as psychosine, has an ability to induce apoptosis in various types of cells including oligodendrocytes. It is a toxic metabolite. Accumulation of this cytotoxic sphingolipid in the brain due to the deficiency of galactocerebrosidase (GALC) leads to the development of Krabbe disease.
Packaging
5 mL Amber Glass Screw Cap Vial (860637P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Flash Point(F)
No data available
Flash Point(C)
No data available
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Victoria Schiffer et al.
PloS one, 15(1), e0227077-e0227077 (2020-01-14)
Gaucher disease is caused by a deficiency in glucocerebrosidase that can result in non-neuronal as well as neuronal symptoms. Common visceral symptoms are an increased organ size, specifically of the spleen, and glucosylceramide as well as glucosylsphingosine substrate accumulations as
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