810186P
Avanti
TopFluor™ PI(3,5)P2
Avanti Research™ - A Croda Brand
Synonym(s):
1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-3,5-bisphosphate (ammonium salt)
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About This Item
Empirical Formula (Hill Notation):
C50H92BF2N6O20P3
CAS Number:
Molecular Weight:
1239.02
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
TopFluor™ PI(3,5)P2, Avanti Research™ - A Croda Brand 810186P, powder
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (with stopper and crimp cap (810186P-50ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 810186P
shipped in
dry ice
storage temp.
−20°C
Related Categories
General description
PI(3,5)P2 (1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-3,5-bisphosphate) is an endosomal lipid. It is produced by Fab1 phosphatidylinositol-3-phosphate 5-kinase from phosphatidylinositol 3-phosphate. This synthesis occurs in the lysosomal membranes.
Biochem/physiol Actions
Phosphatidylinositol phosphate lipids are associated with serval cell signalling pathways. It participates in the transport of peripheral membrane proteins along the plasma membrane. PI(3,5)P2 is essential for endosome maturation.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (810186P-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
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Interactions and Translational Dynamics of Phosphatidylinositol Bisphosphate (PIP2) Lipids in Asymmetric Lipid Bilayers.
Shi X, et al.
Testing, 32(41), 1732-1741 (2016)
The phosphatidylinositol 3, 5-bisphosphate (PI (3, 5) P2)-dependent Tup1 conversion (PIPTC) regulates metabolic reprogramming from glycolysis to gluconeogenesis
Han BK and Emr SD
The Journal of Biological Chemistry, 288(28), 20633-20645 (2013)
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection
Nelson EA, et al.
PLoS Neglected Tropical Diseases, 11(4), e0005540-e0005540 (2017)
Xiaojun Shi et al.
Langmuir : the ACS journal of surfaces and colloids, 32(7), 1732-1741 (2016-02-02)
Phosphatidylinositol phosphate (PIP) lipids are critical to many cell signaling pathways, in part by acting as molecular beacons that recruit peripheral membrane proteins to specific locations within the plasma membrane. Understanding the biophysics of PIP-protein interactions is critical to developing
Bong-Kwan Han et al.
The Journal of biological chemistry, 288(28), 20633-20645 (2013-06-05)
Glucose/carbon metabolism is a fundamental cellular process in living cells. In response to varying environments, eukaryotic cells reprogram their glucose/carbon metabolism between aerobic or anaerobic glycolysis, oxidative phosphorylation, and/or gluconeogenesis. The distinct type of glucose/carbon metabolism that a cell carries
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