700040P
Avanti
desmosterol-d6
Avanti Research™ - A Croda Brand
Synonym(s):
24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)
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About This Item
Empirical Formula (Hill Notation):
C27H38OD6
CAS Number:
Molecular Weight:
390.67
MDL number:
UNSPSC Code:
12352100
NACRES:
NA.25
description
cholesta-5,24-dien-3β-ol-d6
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700040P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.
Application
Desmosterol-d6 has been used:
- as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
- as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
- for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis
Biochem/physiol Actions
Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.
Packaging
5 mL Amber Glass Screw Cap Vial (700040P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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Valerie A Villareal et al.
ACS chemical biology, 11(7), 1827-1833 (2016-04-30)
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These observations suggest a model in which desmosterol
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