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912883

tBuBrettPhos Pd G6 TES

powder

Synonym(s):

tBuBrettPhos OAC precatalyst TES

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About This Item

Empirical Formula (Hill Notation):
C43H66BrO4PPdSi
CAS Number:
2097600-19-4
Molecular Weight:
892.37
MDL number:
MFCD34789852
UNSPSC Code:
12352100
NACRES:
NA.22
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Product Name

tBuBrettPhos Pd G6 TES,

Quality Level

100

product line

Buchwald precatalyst Generation 6

form

powder

reaction suitability

reagent type: catalyst
reaction type: Cross Couplings

mp

>300 °C

SMILES string

[Pd](Br)c3ccc(cc3)C(=O)OCC[Si](C)(C)C.P(C(C)(C)C)(C(C)(C)C)c1c(ccc(c1c2c(cc(cc2C(C)C)C(C)C)C(C)C)OC)OC

InChI key

ZIQMRJCMTGYLPQ-UHFFFAOYSA-M

Application

tBuBrettPhos Pd G6 TES is a G6 Buchwald precatalyst. The G6 precatalysts are air-stable, palladium-based oxidative addition complexes (OACs) that offer an alternative to the previously developed classes of palladacycle precatalysts. Unlike previous generations, the bulkiest biarylphosphine ligand precatalysts are readily prepared. These precatalysts have been shown to be effective for many reactions, including C-N, C-O, and C-F cross couplings.

Learn more about G6 Buchwald precatalysts

Other Notes

Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

Monophosphine Ligands Promote Pd-Catalyzed C-S Cross-Coupling Reactions at Room Temperature with Soluble Base

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Buchwald G6 Precatalysts: Oxidative Addition Complexes

Buchwald G6 precatalysts are oxidative addition complexes that are thermally, air, and moisture stable. The catalyst activation doesn’t require a base and generates innocuous byproducts.

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Monophosphine Ligands Promote Pd-Catalyzed C-S Cross-Coupling Reactions at Room Temperature with Soluble Bases.
Xu J, et al.
ACS Catalysis, 9(7), 6461-6466 (2019)
Bryan T Ingoglia et al.
Organic letters, 19(11), 2853-2856 (2017-05-13)
In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C-N, C-O, and C-F cross-coupling reactions with a variety of (hetero)arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts

Global Trade Item Number

SKUGTIN
912883-100MG04061841784159
912883-1G04061841784166