777692
(1,10-Phenanthroline)(trifluoromethyl)copper(I)
90%
Synonym(s):
Trifluoromethylator®
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About This Item
Empirical Formula (Hill Notation):
C13H8CuF3N2
CAS Number:
Molecular Weight:
312.76
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
MDL number:
Assay:
90%
Form:
solid
assay
90%
form
solid
storage temp.
2-8°C
InChI
1S/C12H8N2.CF3.Cu/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;2-1(3)4;/h1-8H;;
InChI key
CUQZQRIIFNWQSJ-UHFFFAOYSA-N
General description
(1,10-Phenanthroline)(trifluoromethyl)copper(I) [(Phen)Cu-CF3] can be prepared by treating [CuOt-Bu]4 with 1,10-phenanthroline, followed by the addition of (trifluoromethyl)trimethylsilane (CF3TMS). It is an easily handled, thermally stable, single-component reagent.
Application
Trifluoromethylator, A New Arene Trifluoromethylation Reagent: (Phen)Cu-CF3
(Phen)Cu-CF3 can be used as a reagent for the trifluoromethylation of aryl iodides. Electron-rich and electron-deficient iodoarenes, as well as sterically-hindered iodoarenes, react in high yield under mild conditions. Electrophilic functional groups, including aldehydes, nitroarenes, ketones, and esters are tolerated. The substrate scope of this reagent is broad and the reagent has wide applicability for trifluoromethylation reactions.
It can also be used in the oxidative trifluoromethylation of organoboron reagents, and terminal alkynes through C-H activation.
(Phen)Cu-CF3 can be used as a reagent for the trifluoromethylation of aryl iodides. Electron-rich and electron-deficient iodoarenes, as well as sterically-hindered iodoarenes, react in high yield under mild conditions. Electrophilic functional groups, including aldehydes, nitroarenes, ketones, and esters are tolerated. The substrate scope of this reagent is broad and the reagent has wide applicability for trifluoromethylation reactions.
It can also be used in the oxidative trifluoromethylation of organoboron reagents, and terminal alkynes through C-H activation.
Legal Information
Trifluoromethylator is a registered trademark of Catylix, Inc
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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유기 반응 툴박스는 고유한 화학 반응을 위한 구조 활성(structure-activity) 관계를 제공하여 소형 분자 합성을 최적적으로 디자인하고 조절합니다.
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An organic reaction toolbox provides structure-activity relationships for unique chemical reactions to optimally design and control small molecule synthesis.
A broadly applicable copper reagent for trifluoromethylations and perfluoroalkylations of aryl iodides and bromides.
Hiroyuki Morimoto et al.
Angewandte Chemie (International ed. in English), 50(16), 3793-3798 (2011-03-29)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 777692-1G | 04061832940632 |
| 777692-100G | 04061833315040 |
| 777692-10G | 04061832940625 |
| 777692-500MG | 04061833242711 |