A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug

Dual polymeric prodrug co-assembled nanoparticles with precise ratiometric co-delivery of cisplatin and metformin for lung cancer chemoimmunotherapy.

Tong Yang et al.

Biomaterials science, 8(20), 5698-5714 (2020-09-16)

The combination therapy of cisplatin (CDDP) and metformin (MET) is a clinical strategy to enhance therapeutic outcomes in lung cancer. However, the efficacy of this combination is limited due to the asynchronous pharmacokinetic behavior of CDDP and MET, used as

Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution.

Yiyuan Guo et al.

Expert opinion on drug delivery, 17(3), 407-421 (2020-02-06)

Background: Natamycin is the only topical ophthalmic antifungal drug approved by the Food and Drug Administration (FDA) of the United States, but has unsatisfactory factors such as high dosing frequency.Methods: We report the synthesis and preparation of self-assembled poly(ethylene glycol)-block-poly(glycidyl

Controlled Arrangement of Gold Nanoparticles on Planar Surfaces via Constrained Dewetting of Surface-Grafted RAFT Polymer.

Katharina Hendrich et al.

Polymers, 12(6) (2020-05-30)

Linear and four-arm star polystyrene samples prepared by RAFT polymerization were grafted to gold surfaces directly via their thiocarbonylthio-end groups. Nanoscale polymer patterns were subsequently formed via constrained dewetting. The patterned polymer films then served as a template for the

RAFT Agent Design and Synthesis

Keddie, D. J.; et al.

Macromolecules, 45, 5321-5342 (2012)

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가역적 첨가 분해 연쇄 이동(RAFT) 중합

RAFT(가역적 첨가 분해 연쇄 이동) 중합은 RDRP(가역 불활성 라디칼 중합)이며, 라디칼 중합에 리빙 특성을 제공하는 다목적 방법 중 하나입니다.

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The modification of biomacromolecules, such as peptides and proteins, through the attachment of synthetic polymers has led to a new family of highly advanced biomaterials with enhanced properties.

RAFT Polymerization

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We present an article about RAFT, or Reversible Addition/Fragmentation Chain Transfer, which is a form of living radical polymerization.

RAFT Polymerization Procedures

RAFT polymerization offers precise control, enabling tailored synthesis of complex polymer structures.

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Polymerization via ATRP procedures demonstrated by Prof. Dave Haddleton's research group at the University of Warwick.

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4-Cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanoic acid

97% (HPLC)

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