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B9385

Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride

Name: Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₄₅N₇O₇

CAS Number:

70375-24-5

Molecular Weight:

627.73

NACRES:

NA.32

PubChem Substance ID:

24892134

UNSPSC Code:

12352204

MDL number:

MFCD00058181

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Properties

assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

water: 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H45N7O7.ClH/c1-17(2)25(37-30(43)45-31(4,5)6)28(42)38-14-8-10-22(38)27(41)36-21(9-7-13-34-29(32)33)26(40)35-19-11-12-20-18(3)15-24(39)44-23(20)16-19;/h11-12,15-17,21-22,25H,7-10,13-14H2,1-6H3,(H,35,40)(H,36,41)(H,37,43)(H4,32,33,34);1H

InChI key

ROQGJTZGLVLVIN-UHFFFAOYSA-N

Description

General description

A fluorogenic substrate for thrombin.

Boc-Val-Pro-Arg-AMC serves as a synthetic substrate for human kallikrein 8.

Application

Boc-Val-Pro-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a fluorogenic substrate for thrombin in inhibitory assay with salivary protein cE5
as a fluorogenic substrate for thrombin in inhibitory assay with recombinant E. nipponicum serpin
as a substrate in proteinase assay with hemolymph protein

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protocols

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

Global Trade Item Number

SKU	GTIN
B9385-5MG	04061833443736