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6.18723

NMP

suitable for chromatography

Synonym(s):

1-Methyl-2-pyrrolidone

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About This Item

Empirical Formula (Hill Notation):
C5H9NO
CAS Number:
872-50-4
Molecular Weight:
99.13
UNSPSC Code:
12352005
MDL number:
MFCD00003193
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Product Name

1-Methyl-2-pyrrolidone, suitable for chromatography

suitability

suitable for chromatography

Quality Level

100

SMILES string

N1(CCCC1=O)C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

General description

1-Methyl-2-pyrrolidone is a dipolar aprotic solvent widely used in organic chemistry for its ability to dissolve many chemicals. It is commonly used as a solvent or eluent for extracting soluble materials from soil samples using size-exclusion chromatography. NMP is a highly polar liquid and can be used for solvent extraction of polar substances from non-polar substances.

Application


  • Delivery of atovaquone and proguanil across sublingual membranes, in vitro.: This study explores the sublingual delivery of the antimalarial drugs atovaquone and proguanil, using 1-Methyl-2-pyrrolidone (NMP) as a solubilizing agent to enhance drug permeability. Results demonstrate NMP′s potential to improve drug delivery efficiency through sublingual membranes (Wallace et al., 2012).

  • Controlled delivery of aspirin: effect of aspirin on polymer degradation and in vitro release from PLGA based phase sensitive systems.: This research investigates the controlled release of aspirin from poly(lactic-co-glycolic acid) (PLGA) systems using NMP. The study highlights NMP′s role in modulating polymer degradation and drug release profiles, offering insights for developing controlled delivery systems (Tang and Singh, 2008).


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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

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