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31107-M

Ammonium chloride

puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5%

Synonym(s):

Salmiac

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About This Item

Linear Formula:
NH4Cl
CAS Number:
12125-02-9
Molecular Weight:
53.49
NACRES:
NA.21
PubChem Substance ID:
329753648
eCl@ss:
38050207
UNSPSC Code:
12352300
EC Number:
235-186-4
MDL number:
MFCD00011420
Beilstein/REAXYS Number:
4371014
Assay:
≥99.5%
Form:
crystalline powder
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Quality Level

100

agency

USP/NF, reag. ISO, reag. Ph. Eur.

vapor density

1.9 (vs air)

vapor pressure

1 mmHg ( 160.4 °C)

grade

ACS reagent, puriss. p.a.

assay

≥99.5%

form

crystalline powder

impurities

acidity or alkalinity, complies, bromides and iodides, complies, ≤0.005% insoluble matter

pH

4.5-5.5 (20 °C, 5%)

mp

340 °C (subl.) (lit.)

anion traces

nitrate (NO3-): ≤5 mg/kg, phosphate (PO43-): ≤2 mg/kg, sulfate (SO42-): ≤20 mg/kg

cation traces

As: ≤0.00005%, Ca: ≤0.0005%, Cu: ≤0.0002%, Fe: ≤0.0002%, K: ≤0.005%, Mg: ≤0.0005%, Na: ≤0.005%, Ni: ≤0.0001%, Pb: ≤0.0001%, Zn: ≤0.0002%, heavy metals: ≤5 mg/kg (by ICP-OES)

suitability

complies for appearance of solution

SMILES string

N.Cl

InChI

1S/ClH.H3N/h1H;1H3

InChI key

NLXLAEXVIDQMFP-UHFFFAOYSA-N

Application

Ammonium chloride can be used as a catalyst:
  • To synthesize 3,4-dihydropyrimidin-2-(1H)-ones via solvent-free Biginelli condensation reaction.
  • For the aldol condensation of carbonyl compounds.
  • In the thia-Michael addition reaction of thiols to different α-enones.
It can also be used as:
  • A promoter in the enantioselective hydrogenation of an unprotected β-enamine amides.
  • A pH-adjuster in the preparation of waterborne glucose silicone resin.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

12125-02-9

CAS No.

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Ammonium chloride-catalyzed one-pot synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions
Shaabani A, et al.
Tetrahedron Letters, 44, 857-859 (2003)
Neutron diffraction study of the crystal structure of ammonium chloride.
Levy, Henri A., and S. W. Peterson.
Physical Review, 86(5), 766-766 (1952)
Barbara Nozière et al.
Physical chemistry chemical physics : PCCP, 12(15), 3864-3872 (2010-04-02)
In natural environments such as atmospheric aerosols, organic compounds coexist with inorganic salts but, until recently, were not thought to interact chemically. We have recently shown that inorganic ammonium ions, NH(4)(+), act as catalysts for acetal formation from glyoxal, a