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Merck

724815

Poly(N-isopropylacrylamide), carboxylic acid terminated

average Mn 2,000

Synonym(s):

NIPAM polymer, PNIPAM-COOH, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
(C6H11NO)nSCH2CH2CO2H
NACRES:
NA.23
UNSPSC Code:
12162002
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form

powder

Quality Level

mol wt

average Mn 2,000

mp

>300 °C

Application

Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The carboxylic acid functional group can be used to conjugate a variety of biomolecules to the polymer chain.


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Articles

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

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Global Trade Item Number

SKUGTIN
724815-1G04061826644553
724815-5G04061835512072