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T2528

Terbutaline hemisulfate salt

β-adrenoceptor agonist

Synonyme(s) :

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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A propos de cet article

Formule linéaire :
C12H19NO3 · 1/2H2SO4
Numéro CAS:
23031-32-5
Poids moléculaire :
274.32
NACRES:
NA.77
PubChem Substance ID:
24278729
UNSPSC Code:
12352200
EC Number:
245-386-3
MDL number:
MFCD00079584
Quality level:
100
Service technique
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Nom du produit

Terbutaline hemisulfate salt,

Quality Level

100

solubility

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

originator

Novartis

SMILES string

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChI key

KFVSLSTULZVNPG-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

Application

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.

Biochem/physiol Actions

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.

Features and Benefits

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H361,H370

Hazard Classifications

Repr. 2 - STOT SE 1

target_organs

Cardio-vascular system

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number
028K1050
018K1636
127K1112
076K1725
095K1629

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Consulter la Bibliothèque de documents

J Elers et al.
International journal of sports medicine, 33(12), 1026-1033 (2012-07-12)
We examined urine and serum concentrations after therapeutic use of single and repetitive doses of inhaled and supratherapeutic oral use of terbutaline. We compared the concentrations in 10 asthmatics and 10 healthy subjects in an open-label, cross-over study with 2
Andrew H Travers et al.
The Cochrane database of systematic reviews, 12, CD010179-CD010179 (2012-12-14)
Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents. To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma
K Törneke et al.
Journal of veterinary pharmacology and therapeutics, 21(5), 388-392 (1998-11-12)
Beta2-adrenoceptor agonists are used as bronchodilators in both humans and horses. Of these drugs, clenbuterol is the one most frequently used when treating chronic obstructive pulmonary disease in the horse, while salbutamol and terbutaline are used in the treatment of
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Numéro d'article de commerce international

RéférenceGTIN
T2528-1G04061837342288
T2528-5G04061837342295