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SML1313

BMS 204352

≥98% (HPLC)

Synonyme(s) :

(3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one

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A propos de cet article

Formule empirique (notation de Hill) :
C16H10ClF4NO2
Numéro CAS:
187523-35-9
Poids moléculaire :
359.70
NACRES:
NA.77
PubChem Substance ID:
329825778
UNSPSC Code:
12352200
MDL number:
MFCD09475617
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1NC2=CC(C(F)(F)F)=CC=C2[C@@]1(C3=CC(Cl)=CC=C3OC)F

InChI

1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1

InChI key

ULYONBAOIMCNEH-HNNXBMFYSA-N

Gene Information

human ... KCNMA1(3778), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479)

Application

BMS 204352 has been used in drug administration.

Biochem/physiol Actions

BMS 204352 is a potassium channel modulator.
BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.
BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to treat ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamily, member 4) and KCNQ5 (KQT-like subfamily, member 5) with equal potency.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Consulter la Bibliothèque de documents

Mohammad Al-Mahdi Al-Karagholi et al.
Cephalalgia : an international journal of headache, 40(11), 1145-1154 (2020-08-28)
Preclinical data implicate large conductance calcium-activated potassium (BKCa) channels in the pathogenesis of headache and migraine, but the exact role of these channels is still unknown. Here, we investigated whether opening of BKCa channels would cause headache and vascular effects
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.
Hebert B, et al.
Orphanet Journal of Rare Diseases, 9(1), 124-124 (2014)
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
Song T, et al.
PLoS Genetics, 14(1), e1007165-e1007165 (2018)
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Numéro d'article de commerce international

RéférenceGTIN
SML1313-25MG04061832577081
SML1313-5MG04061832577098