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P3972

Progesterone

Name: Progesterone
Brand: SIGMA

meets USP testing specifications

Synonyme(s) :

4-Pregnene-3,20-dione

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₁H₃₀O₂

Numéro CAS:

57-83-0

Poids moléculaire :

314.46

UNSPSC Code:

41116107

NACRES:

NA.21

PubChem Substance ID:

24898476

EC Number:

200-350-6

Beilstein/REAXYS Number:

1915950

MDL number:

MFCD00003658

Assay:

≥97%

Form:

solid

Service technique

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Propriétés

agency

USP/NF, meets USP testing specifications

assay

≥97%

form

solid

mp

128-132 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Description

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Induit la maturation et l′activité secrétoire de l′endothélium utérin ; supprime l′ovulation.

Other Notes

Steroid hormone produced by the corpus luteum.

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pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

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Articles

LC-MS Analysis of Hormones in Tap Water

Milli-Q® ultrapure water systems deliver water free of organic contaminants , including hormones present in a lab's tap water, making it suitable for the most sensitive LC-MS/MS analyses.

Analyse de traces d'hormones dans l'eau de ville par LC-MS

Les systèmes d'eau ultra pure Milli-Q® fournissent une eau exempte de contaminants organiques, y compris d'hormones présentes dans l'eau de ville d'un laboratoire, ce qui la rend adaptée aux analyses LC-MS/MS les plus sensibles.

Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells.

Koji Mizuhashi et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(8), 1387-1392 (2019-03-20)

The growth plate provides a substantial source of mesenchymal cells in the endosteal marrow space during endochondral ossification. The current model postulates that a group of chondrocytes in the hypertrophic zone can escape from apoptosis and transform into cells that

Hippocampal volume and functional connectivity changes during the female menstrual cycle.

Nina Lisofsky et al.

NeuroImage, 118, 154-162 (2015-06-10)

Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle.

Complex biological pattern of fertility hormones in children and adolescents: a study of healthy children from the CALIPER cohort and establishment of pediatric reference intervals.

Danijela Konforte et al.

Clinical chemistry, 59(8), 1215-1227 (2013-05-03)

Pediatric endocrinopathies are commonly diagnosed and monitored by measuring hormones of the hypothalamic-pituitary-gonadal axis. Because growth and development can markedly influence normal circulating concentrations of fertility hormones, accurate reference intervals established on the basis of a healthy, nonhospitalized pediatric population

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Numéro d'article de commerce international

Référence	GTIN
P3972-25G	04061834373360
P3972-5G	04061834373377