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L1012

Acide linoléique

Name: Acide linoléique
Brand: SIGMA

liquid, BioReagent, suitable for cell culture

Synonyme(s) :

Acide cis-9,cis-12-octadecadiénoïque

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A propos de cet article

Formule linéaire :

CH₃(CH₂)₄CH=CHCH₂CH=CH(CH₂)₇CO₂H

Numéro CAS:

60-33-3

Poids moléculaire :

280.45

NACRES:

NA.75

PubChem Substance ID:

24896270

eCl@ss:

32190102

UNSPSC Code:

12352211

EC Number:

200-470-9

MDL number:

MFCD00064241

Beilstein/REAXYS Number:

1727101

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Propriétés

biological source

plant (Safflower oil)

Quality Level

200

product line

BioReagent

assay

≥98%

form

liquid

technique(s)

cell culture | mammalian: suitable

refractive index

n20/D 1.466 (lit.)

bp

229-230 °C/16 mmHg (lit.)

mp

−5 °C (lit.)

solubility

NaOH: 1 M, ethanol: soluble

density

0.902 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

OC(CCCCCCC/C=C\C/C=C\CCCCC)=O

InChI

1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-

InChI key

OYHQOLUKZRVURQ-HZJYTTRNSA-N

Gene Information

human ... SOAT1(6646), SOAT2(8435)

Description

General description

Linoleic acid (LA) is the precursor for the synthesis of arachidonic prostaglandins and other eicosanoids. LA is present in vegetable oils and meat.

Application

Linoleic acid has been used as a component of S12 medium for cardiomyocytes differentiation, minimum essential medium α for spermatogonial stem cell culture and for endothelial differentiation of mouse adipose-derived stem cells (mASC).

Fatty acid that is typically bound to a carrier molecule such as BSA or cyclodextrin for use in cell culture.

Biochem/physiol Actions

L'acide linoléique augmente la prolifération cellulaire ainsi que l'expression des gènes du récepteur PPARα et de ses gènes cibles tels que l'acyl-CoA oxydase dans les lignées primaires d'hépatocytes de canard.

Linoleic acid (LA) may improve wound healing in diabetic rat. The levels of LA in adipose tissue and platelets are correlated with coronary artery disease. It may induce tumor and apoptosis in colorectal cancer cells. Studies also support their protective effects in lymphocytes. Linoleic acid is typically bound to a carrier molecule such as bovine serum albumin (BSA) or cyclodextrin for use in cell culture.

Packaging

Sealed ampule.

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Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

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Protocoles

Primary Human Hepatocytes Culture Protocol

Discover our primary human hepatocytes and plating and maintenance media formulations. Explore our protocol for plateable primary hepatocyte cell culture.

Primary Human Spheroid-Qualified Plateable Hepatocyte Culture Protocol

Discover our protocol for thawing, plating, and forming hepatocyte spheroids from human spheroid-qualified plateable hepatocytes. Find the formulation for hepatocyte spheroid maintenance media.

Articles

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Contenu apparenté

Primary Human Suspension Hepatocytes Culture Protocol

Explore our protocol for suspension primary hepatocyte cell culture. Discover our primary human hepatocytes and plating and maintenance media formulations.

Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells

Pei F, et al.

Stem Cell Research, 19(6), 94-103 (2017)

Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells

Zhang X, et al.

Stem Cell Research, 20(6), 21-29 (2017)

Enhancement effects of BSA and linoleic acid on hybridoma cell growth and antibody production

Cytotechnology, 112(6), 51-56 (1994)

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Numéro d'article de commerce international

Référence	GTIN
L1012-5G	04061833949160
L1012-100MG	04061833949146
L1012-1G	04061833949153