L0649
Leupeptin hydrochloride
powder, ≥70% (HPLC)
Synonyme(s) :
Acetyl-Leu-Leu-Arg-al hydrochloride
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A propos de cet article
Formule empirique (notation de Hill) :
C20H38N6O4 · HCl
Numéro CAS:
Poids moléculaire :
463.01
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Leupeptin hydrochloride, microbial, ≥70% (HPLC)
biological source
microbial
Quality Level
assay
≥70% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to yellow
storage temp.
−20°C
SMILES string
Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
InChI
1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
InChI key
OQQYPQNFLLAILR-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
Analysis Note
Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenu apparenté
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Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| L0649-100MG | 04061833262986 |
| L0649-25MG | 04061833948910 |
| L0649-5MG | 04061833948927 |