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H6167

Cholestérol

Name: Cholestérol
Brand: SIGMA

from sheep wool, Controlled origin, meets USP/NF testing specifications

Synonyme(s) :

3β-hydroxy-5-cholestène, 5-Cholestén-3β-ol

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₇H₄₆O

Numéro CAS:

57-88-5

Poids moléculaire :

386.65

UNSPSC Code:

12352211

NACRES:

NA.21

PubChem Substance ID:

329815229

EC Number:

200-353-2

Beilstein/REAXYS Number:

1915888

MDL number:

MFCD00003646

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Propriétés

biological source

sheep wool

Quality Level

300

agency

meets USP/NF testing specifications

form

powder

origin

Australia origin, New Zealand origin

bp

360 °C (lit.)

mp

147-149 °C (lit.)

solubility

water: soluble 0.00003 g/L at 20 °C

density

1.067 g/mL at 25 °C (lit.)

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

Description

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Biochem/physiol Actions

Constituant majeur de toutes les membranes biologiques ; le cholestérol représente ~25 % des lipides totaux du cerveau.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation.

Jinjiang Fan et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(23), 7261-7266 (2015-06-04)

Translocator protein (TSPO) is a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues. To assess the function of TSPO, we generated two lines of Cre-mediated Tspo conditional knockout (cKO) mice. First, gonadal somatic cell-targeting Amhr2-Cre mice were

Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial.

James I Dower et al.

The American journal of clinical nutrition, 101(5), 914-921 (2015-05-03)

Prospective cohort studies showed inverse associations between the intake of flavonoid-rich foods (cocoa and tea) and cardiovascular disease (CVD). Intervention studies showed protective effects on intermediate markers of CVD. This may be due to the protective effects of the flavonoids

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial.

Frederick J Raal et al.

Lancet (London, England), 385(9965), 331-340 (2014-10-06)

Heterozygous familial hypercholesterolaemia is characterised by low cellular uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature cardiovascular disease. Despite intensive statin therapy, with or without ezetimibe, many patients are unable to achieve recommended target levels of LDL

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Numéro d'article de commerce international

Référence	GTIN
H6167-1KG	04061826004814
H6167-100G	04061832608525