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H3631

Hyaluronidase from bovine testes

Type VI-S, lyophilized powder, 3,000-15,000 units/mg solid

Synonyme(s) :

Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase

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A propos de cet article

Numéro CAS:
37326-33-3
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
253-464-3
MDL number:
MFCD00131351
Numéro CE :
3.2.1.35 (BRENDA, IUBMB)
Specific activity:
3,000-15,000 units/mg solid
Biological source:
bovine testis
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biological source

bovine testis

Quality Level

200

conjugate

conjugate (Glucosaminoglycan)

type

Type VI-S

form

lyophilized powder

specific activity

3,000-15,000 units/mg solid

mol wt

~55 kDa (four subunits of 14 kDa each)

UniProt accession no.

Q5E985, Q8SQG8

relevant disease(s)

cancer

storage temp.

−20°C

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Biochem/physiol Actions

Ces enzymes coupent de façon aléatoire les liaisons glycosidiques β-N-acétylhexosamine-[1→4] dans l′acide hyaluronique, la chondroïtine et les sulfates de chondroïtine.
L′hyaluronidase dégrade l′hyaluronane et elle semble être régulée de façon anormale lors de la progression du cancer.

Preparation Note

Chromatographically purified

Other Notes

One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).
View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
117K7010
113K7000
073H8015
048H7005
022H8045

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Protocoles

Enzymatic Assay of Hyaluronidase (3.2.1.35)

To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.

Articles

What is Hyaluronan?

Explore the role of hyaluronan, hyaluronic acid structure, hyaluronan synthesis & degradation, and more. Find GAGs, hydrogels, and scaffold kits.

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Tongcui Ma et al.
eLife, 11 (2022-07-06)
High-parameter single-cell phenotyping has enabled in-depth classification and interrogation of immune cells, but to date has not allowed for glycan characterization. Here, we develop CyTOF-Lec as an approach to simultaneously characterize many protein and glycan features of human immune cells
Dong-Ru Ho et al.
International journal of urology : official journal of the Japanese Urological Association, 18(7), 525-531 (2011-05-25)
To investigate how hyaluronic acid (HA) affects nerve growth factor (NGF) production and bladder overactivity in a cyclophosphamide (CYP)-induced cystitis rat model. Female Sprague-Dawley rats received three intermittent intraperitoneal injections of CYP (75 mg/kg) or saline. Before or after CYP injection
Tongcui Ma et al.
eLife, 9 (2020-05-27)
The female reproductive tract (FRT) is the most common site of infection during HIV transmission to women, but viral remodeling complicates characterization of cells targeted for infection. Here, we report extensive phenotypic analyses of HIV-infected endometrial cells by CyTOF, and
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Numéro d'article de commerce international

RéférenceGTIN
H3631-15KU04061833793619
H3631-30KU04061833793657
H3631-3KU04061833793671