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95144

Rétinol

Name: Rétinol
Brand: SIGMA

BioXtra, ≥97.5% (HPLC), ~3100 U/mg

Synonyme(s) :

Alcool de vitamine A, Axérophtol, Vitamine A, Vitamine A₁, tout-trans-3,7-diméthyl-9-(2,6,6-triméthyl-1-cyclohexén-1-yl)-2,4,6,8-nonatétraén-1-ol

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₀H₃₀O

Numéro CAS:

68-26-8

Poids moléculaire :

286.45

NACRES:

NA.28

PubChem Substance ID:

57653654

eCl@ss:

34058018

UNSPSC Code:

12352205

EC Number:

200-683-7

MDL number:

MFCD00001552

Beilstein/REAXYS Number:

403040

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Propriétés

biological source

synthetic

Quality Level

200

product line

BioXtra

assay

≥97.5% (HPLC)

form

(Powder or Powder with Lumps)

specific activity

~3100 U/mg

shelf life

limited shelf life

color

faint yellow to very dark yellow

mp

56-61 °C, 61-63 °C (lit.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

InChI key

FPIPGXGPPPQFEQ-OVSJKPMPSA-N

Description

General description

Retinol or vitamin A alcohol is the main circulating form of vitamin A.

Application

Retinol has been used:

as a standard in peak identification and quantification in reverse phase HPLC
as a standard to estimate the concentration of vitamin A
to study the inhibitory effect of retinol on murine norovirus (MNV) replication in murine RAW 264.7 cells
as a component in the reaction mixture for the lecithin:retinol acyltransferase (LRAT) assay

Biochem/physiol Actions

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinol is biological active in a wide range of processes.

It is not biologically active and works as a precursor of active retinoids. Retinol is converted to retinaldehyde and subsequently to retinoic acid.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H317,H319,H360FD,H413

pcodes

P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number

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Protocoles

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

Contenu apparenté

Data Sheet - 95144

Retinyl palmitate does not have an adjuvant effect on the antibody response of chicks to keyhole limpet hemocyanin regardless of vitamin A status

Livingston KA and Klasing KC

Poultry Science, 90(5), 965-970 (2011)

Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models

Quadro L, et al.

Molecular Aspects of Medicine, 24(6), 421-430 (2003)

Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome

Lee H and Ko G

Scientific reports, 25835-25835 (2016)

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Numéro d'article de commerce international

Référence	GTIN
95144-1G	04061833315637
95144-250MG	04061835512096