42602
Propionyl-L-carnitine
≥94.0% (HPLC), suitable for LC/MS
Synonyme(s) :
(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt, L-Carnitine propionyl ester, C3-Carnitine, Propanoyl-L-carnitine
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A propos de cet article
Formule empirique (notation de Hill) :
C10H19NO4
Numéro CAS:
Poids moléculaire :
217.26
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
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Laissez-nous vous aiderNom du produit
Propionyl-L-carnitine, ≥94.0% (HPLC)
Quality Level
assay
≥94.0% (HPLC)
form
powder or crystals
optical activity
[α]/D -23±3°, c = 1 in H2O
technique(s)
LC/MS: suitable
impurities
≤10% water (calcd. from elemental analysis)
color
white to off-white
storage temp.
2-8°C
SMILES string
[O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O
InChI
1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1
InChI key
UFAHZIUFPNSHSL-MRVPVSSYSA-N
General description
Propionyl-L-carnitine (PLC) is a short-chain fatty acid ester derivative of carnitine.
Application
Propionyl-L-carnitine has been used as a standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Biochem/physiol Actions
Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation. PLC has the potential to treat severe peripheral arterial disease and chronic heart failure. It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Santica M Marcovina et al.
Translational research : the journal of laboratory and clinical medicine, 161(2), 73-84 (2012-11-10)
Mitochondria play important roles in human physiological processes, and therefore, their dysfunction can lead to a constellation of metabolic and nonmetabolic abnormalities such as a defect in mitochondrial gene expression, imbalance in fuel and energy homeostasis, impairment in oxidative phosphorylation
M J Cipolla et al.
Journal of vascular surgery, 29(6), 1097-1103 (1999-06-09)
The vasoactive effects of propionyl-L-carnitine (PLC) on human arteries, including endothelial and smooth muscle cell influences, were studied. Small (less than 200 microm) subcutaneous fat arteries (n = 19), obtained from human patients undergoing vascular surgery, were dissected and mounted
William R Hiatt et al.
Journal of cardiopulmonary rehabilitation and prevention, 31(2), 125-132 (2010-09-24)
Exercise training is established for the treatment of peripheral artery disease; however the additional benefit of pharmacologic therapy with exercise has not been studied. This trial tested the hypothesis that propionyl-L-carnitine (PLC), in combination with monitored home-based exercise training, would
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 42602-50MG | 04061833411308 |
| 42602-10MG | 04061833380666 |