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16758

Poly(éthylene glycol)-blocage-poly(propylène glycol)-blocage-poly(éthylene glycol)

Name: Poly(éthylene glycol)-<I>blocage</I>-poly(propylène glycol)-<I>blocage</I>-poly(éthylene glycol)
Brand: SIGMA

purified, non-ionic

Synonyme(s) :

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

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A propos de cet article

Numéro CAS:

9003-11-6

UNSPSC Code:

12352104

NACRES:

NA.25

MDL number:

MFCD00082049

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Propriétés

Quality Level

100

form

powder

quality

purified

impurities

≤1.0% water

pH

5.0-7.5

solubility

soluble, clear, colorless

cation traces

Al: ≤5 mg/kg, As: ≤0.05 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤1000 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

UV absorption

λ: 260 nm A_max: ≤0.3, λ: 280 nm A_max: ≤0..2

suitability

no residue for filter test

storage temp.

2-8°C

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Application

Poloxamer 407 has been used:

as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
for VLDL secretion assay in mice
to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Biochem/physiol Actions

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

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Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Numéro d'article de commerce international

Référence	GTIN
I6758-10G	04061835367061
I6758-1G	04061835367078
I6758-5G	04061835367085
420290-5GM	04055977210828
420291-100GM	04055977210859
420291-1GM	04055977210835
420291-1KG	04055977210842
420291-250GM	04055977210873
420291-25GM	04055977210866
420291-5GM	07790788050108
420322-10GM	07790788055622
420322-1KG	04055977210569
420322-500GM	07790788050153
420322-100GM	07790788050146
420322-110GM	04055977210590
420322-1GM	04055977210552
420322-25GM	07790788057817
420322-3.5KG	04055977210613
420322-5GM	04055977210620
420322-85GM	04055977210644
70527-3	07790788052690
70527-500ML	04054839556845