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S3674

Acide succinique

Name: Acide succinique
Brand: SIAL

BioXtra, BioRenewable, ≥99.0%

Synonyme(s) :

Acide butanedioïque

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A propos de cet article

Formule linéaire :

HOOCCH₂CH₂COOH

Numéro CAS:

110-15-6

Poids moléculaire :

118.09

UNSPSC Code:

12352106

NACRES:

NA.25

PubChem Substance ID:

24899568

EC Number:

203-740-4

Beilstein/REAXYS Number:

1754069

MDL number:

MFCD00002789

Assay:

≥99.0%

Service technique

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Propriétés

Quality Level

200

product line

BioXtra

assay

≥99.0%

greener alternative product characteristics

Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.01% Insoluble matter

ign. residue

≤0.02%

bp

235 °C (lit.)

mp

184-186 °C (lit.)

solubility

H₂O: 0.5 M, clear, colorless

anion traces

chloride (Cl^-): ≤0.001%, sulfate (SO₄^2-): ≤0.003%

cation traces

Al: ≤0.0005%, Ca: ≤0.001%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH₄⁺: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

greener alternative category

, Aligned

SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is biobased and thus aligns with "Use of Renewable Feedstocks". Click here for more information.

Application

Succinic acid has been used:

in succinate dehydrogenase mitochondrial assay.
as an internal standard in mass spectroscopy.
as succinate dehydrogenase substrate in oxygraph analysis to measure respiration rates.

Biochem/physiol Actions

Succinic acid is a byproduct of anaerobic fermentation in microbes. It is a dicarboxylic acid and an intermediate in Kreb′s cycle. Polymorphism in succinate dehydrogenase leads to succinate accumulation. High levels of succinate impairs 2-oxoglutarate epigenetic signalling. Succinate levels may modulate tumor progression. Succinate inhibits histone demethylation and may contribute to epigenetic changes. Succinate is crucial for interleukin-1 β (IL-1β) synthesis during inflammation and immune signalling.

Other Notes

Succinic Acid: A New Platform Chemical for Biobased Polymers from Renewable Resources

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pictograms

GHS05

signalword

Danger

hcodes

H318

pcodes

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Oncometabolites: Unconventional triggers of oncogenic signalling cascades

Sciacovelli M and Frezza C

Free Radical Biology & Medicine, 100(9), 175-181 (2016)

Screening For Isolation of Succinic Acid Producing Microbes

Hema N and Sreenath KP

Biosciences, Biotechnology Research Asia, 15(2), 327-333 (2018)

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue

Whitaker-Menezes D, et al.

Cell Cycle, 10(23), 4047-4064 (2011)

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Numéro d'article de commerce international

Référence	GTIN
S3674-100G	04061835549412
S3674-1KG	04061836923518
S3674-250G	04061835549429