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PHR1153

Triethyl citrate

greener alternative

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Ethyl citrate

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A propos de cet article

Formule linéaire :
HOC(COOC2H5)(CH2COOC2H5)2
Numéro CAS:
77-93-0
Poids moléculaire :
276.28
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823171
EC Number:
201-070-7
Beilstein/REAXYS Number:
1801199
MDL number:
MFCD00009201
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1683606

vapor density

9.7 (vs air)

vapor pressure

1 mmHg ( 107 °C)

API family

triethyl citrate

CofA

current certificate can be downloaded

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Learn more about the Principles of Green Chemistry.

sustainability

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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.442 (lit.)

bp

235 °C/150 mmHg (lit.)

density

1.14 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

greener alternative category

Aligned

storage temp.

2-30°C

SMILES string

CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC

InChI

1S/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3

InChI key

DOOTYTYQINUNNV-UHFFFAOYSA-N

General description

Triethyl citrate is an ester of citric acid and is commonly used as a plasticizer in pharmaceutical coatings including tablets, capsules, beads and granules for masking taste. It is also used as a flavoring agent in food.

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product can replace highly toxic diluents in membrane preparation and thus aligns with "Less Hazardous Chemical Syntheses". Click here for more information.

Application

Triethyl citrate can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8988 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

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Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

311.0 °F - closed cup

flash_point_c

155 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Ethylcellulose--A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development
Wasilewska K and Winnicka K
Materials, 12(20), 3386-3386 (2019)
Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography
Li Z, et al.
Journal of Chromatography A, 1104(1-2), 1-10 (2006)
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Numéro d'article de commerce international

RéférenceGTIN
PHR1153-1G04061834413578