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MilliporeSigma

PHR1020

Glycérol

greener alternative

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

1,2,3-propanetriol, Glycérine

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A propos de cet article

Formule linéaire :
HOCH2CH(OH)CH2OH
Numéro CAS:
Poids moléculaire :
92.09
UNSPSC Code:
12161500
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-289-5
Beilstein/REAXYS Number:
635685
MDL number:
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Quality Level

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. G0400000, traceable to USP 1295607

vapor density

3.1 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

API family

glycerin

CofA

current certificate can be downloaded

autoignition temp.

698 °F

greener alternative product characteristics

Safer Solvents and Auxiliaries
Design for Degradation
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.474 (lit.)

bp

182 °C/20 mmHg (lit.)

mp

20 °C (lit.)

density

1.25 g/mL (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

greener alternative category

storage temp.

2-30°C

SMILES string

OCC(O)CO

InChI

1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

PEDCQBHIVMGVHV-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. Glycerol, with its high boiling point, low flammability, and polarity, is a standout choice. As a non-toxic and biodegradable compound, it aligns perfectly with the principles of ′Safer Solvents and Auxiliaries′ and ′Design for Degradation′. Click here for more information.

Application

Glycerin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and cosmetics by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7812 in the slot below. This is an example certificate only and may not be the lot that you receive.


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Classe de stockage

10 - Combustible liquids

flash_point_f

390.2 °F - Pensky-Martens closed cup

flash_point_c

199 °C - Pensky-Martens closed cup



Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Method development for the simultaneous determination of five glycols in two commercial cough syrup samples using a capillary GC column by GC-MS/MS.


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Kulkarni SP and Amin PD
Journal of Pharmaceutical and Biomedical Analysis, 23(6), 983-987 (2000)
E Mikami et al.
Journal of pharmaceutical and biomedical analysis, 28(2), 261-267 (2002-04-04)
A high-performance liquid chromatographic (HPLC) method for simultaneous determination of dehydroacetic acid (DHA), benzoic acid (BA), sorbic acid (SOA) and salicylic acid (SA) was developed for application to cosmetic products. Isocratic reversed-phase HPLC was employed for quantitative analysis using tetra-n-butylammonium
Hovsep Mahdessian et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(24), 8913-8918 (2014-06-14)
Genome-wide association studies have identified a locus on chromosome 19 associated with plasma triglyceride (TG) concentration and nonalcoholic fatty liver disease. However, the identity and functional role of the gene(s) responsible for these associations remain unknown. Of 19 expressed genes



Numéro d'article de commerce international

RéférenceGTIN
PHR1020-5G04061837883873