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47673

Formaldéhyde solution

tested according to Ph. Eur.

Synonyme(s) :

Formol

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A propos de cet article

Formule linéaire :
HCHO
Numéro CAS:
50-00-0
Poids moléculaire :
30.03
UNSPSC Code:
12352114
NACRES:
NA.25
PubChem Substance ID:
329757334
MDL number:
MFCD00003274
Beilstein/REAXYS Number:
1209228
eCl@ss:
39021101
Form:
liquid
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Quality Level

200

agency

tested according to Ph. Eur.

vapor density

1.03 (vs air)

vapor pressure

52 mmHg ( 37 °C)

form

liquid

autoignition temp.

572 °F

contains

9.0-15.0 % (v/v) methanol as stabilizer

concentration

25-50%

solubility

water: soluble

density

1.09 g/mL at 25 °C (lit.)

suitability

suitable for manufacturing use (Laboratory chemicals)

SMILES string

[H]C([H])=O

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

Application

Formaldehyde solution has been used to fix labeled cells during flow cytometry.

Biochem/physiol Actions

Formaldehyde is the simplest aldehyde that denatures the bihelical regions of RNA and converts the polynucleotides into random coils. It is a genotoxic substance that significantly induces DNA-protein crosslinks (DPC), sister-chromatid exchanges, micronuclei formation and leads to cytotoxicity. It also induces tumors in the nasal epithelium of rats and supposed to be a human carcinogen.

Disclaimer

may become turbid on storage

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1 - STOT SE 3

target_organs

Eyes,Central nervous system, Respiratory system

Classe de stockage

3 - Flammable liquids

wgk

WGK 3

flash_point_f

133.0 °F - closed cup

flash_point_c

56.11 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificats d'analyse (COA)

Lot/Batch Number

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Dependence of the sedimentation coefficient on molecular weight of RNA after reaction with formaldehyde.
H Boedtker
Journal of molecular biology, 35(1), 61-70 (1968-07-14)
O Merk et al.
Environmental and molecular mutagenesis, 32(3), 260-268 (1998-11-14)
Formaldehyde (FA) is a genotoxic substance, induces tumors in the nasal epithelium of rats, and is suspected to be a human carcinogen. As a primary DNA lesion, FA induces DNA-protein crosslinks (DPC) and the formation of DPC has been used
J L Wilson et al.
Journal of immunology (Baltimore, Md. : 1950), 163(12), 6365-6370 (1999-12-10)
NK cells have the capacity to spontaneously kill tumor cell lines, in particular cell lines of hemopoietic origin. In contrast, they do not generally kill nontransformed autologous cells. However, here we demonstrate that short-term activated polyclonal human NK cells, as
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Numéro d'article de commerce international

RéférenceGTIN
47673-10L-F04061838176950
47673-1L-F04061832372716