07386
Coenzyme Q10
analytical standard
Synonyme(s) :
Q-10, Ubiquinone 50, Ubiquinone-10
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A propos de cet article
Formule empirique (notation de Hill) :
C59H90O4
Numéro CAS:
Poids moléculaire :
863.34
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
206-147-9
Beilstein/REAXYS Number:
1900141
MDL number:
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analytical standard
Quality Level
assay
≥97.5% (HPLC)
form
powder
shelf life
limited shelf life, expiry date on the label
impurities
≤1.0% water
color
faint yellow to dark orange
mp
49 °C
application(s)
cleaning products
cosmetics
food and beverages
personal care
format
neat
storage temp.
−20°C
SMILES string
O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O
InChI
1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
InChI key
ACTIUHUUMQJHFO-UPTCCGCDSA-N
General description
Coenzyme Q10 is the central electron carrier in mitochondrial respiratory chain, originating from food intake as well as from endogenous synthesis. It commonly acts in its reduced form to prevent lipid peroxidation in biological membranes and in serum low-density lipoproteins (LDL). It also tends to protect the mitochondrial membrane proteins and DNA against oxidative damage along with lipid peroxidation.
Application
- Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice: Research demonstrates Coenzyme Q10′s effectiveness in reducing cardiac damage through antioxidant mechanisms and inflammation modulation, offering insights for potential human therapeutic applications (Antar et al., 2024).
- Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10: This study explores how Coenzyme Q10, along with taurine, can mitigate the negative hematological effects of chlorpromazine, suggesting its use in managing side effects in psychiatric treatments (Obukohwo et al., 2024).
- Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms: Discusses the role of Coenzyme Q10 in muscle health, particularly in preventing atrophy through mitochondrial support and enhancing cellular energy metabolism, pertinent for sports medicine and aging (Shen et al., 2024).
- Identification of a family of species-selective complex I inhibitors as potential anthelmintics: Although indirectly related, this study hints at the role of mitochondrial function, which could be linked to Coenzyme Q10′s effects in similar pathways, suggesting a novel application area in parasitology and infectious diseases (Davie et al., 2024).
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Disclaimer
light sensitive
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults
Niklowitz P, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 342(1-2), 219-226 (2004)
Gerwyn Morris et al.
Molecular neurobiology, 48(3), 883-903 (2013-06-14)
Coenzyme Q10 (CoQ10) is an antioxidant, a membrane stabilizer, and a vital cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine triphosphate. It additionally regulates gene expression and apoptosis; is an essential cofactor of uncoupling proteins; and
M Mancuso et al.
Current drug targets, 11(1), 111-121 (2009-12-19)
Coenzyme Q10 (CoQ10, or ubiquinone) is an electron carrier of the mitochondrial respiratory chain (electron transport chain) with antioxidant properties. In view of the involvement of CoQ10 in oxidative phosphorylation and cellular antioxidant protection a deficiency in this quinone would
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 115053-5G | 04061838703057 |
| 115053-1G | 04061821000002 |
| 115053-25G | 04061832104928 |
| 07386-10MG | 04061835560073 |