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MABN77

Anti-Potassium Channel Kv1.2 Antibody, clone K14/16

clone K14/16, from mouse

Synonyme(s) :

potassium voltage-gated channel, shaker-related subfamily, member 2, potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel subunit Kv1.2, Voltage-gated potassium channel HBK5, potassium channel, Voltage-gated K(+) channel

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
K14/16, monoclonal
Application:
IF, IHC, WB
Citations:
3
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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

K14/16, monoclonal

species reactivity

rat

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NP_037102

UniProt accession no.

P63142

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KCNA2(3737)

General description

Potassium channel Kv1.2 is one of many different types of potassium channels in the cell. The Kv family of potassium channels seem to have a conserved homotetramer formation consisting of four voltage sensors and one pore domain. Kv1.2 cooperates with cortactin (an actin cytoskeleton-binding protein) and together they may have a part in the regulation of the ionic current.
~ 65 kDa observed

Immunogen

Recombinant protein corresponding to rat Kv1.2.

Application

Immunofluorescence Analysis: a previous lot of this antibody was used by an independent laboratory in IF. (Yang, J.W., et al. (2007). PNAS. 104(50):20055–20060.)
This Anti-Potassium Channel Kv1.2 Antibody, clone K14/16 is validated for use in IH, WB, IF for the detection of Potassium Channel Kv1.2.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in rat brain membrane tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Kv1.2 on 10 µg of rat brain membrane tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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De-En Xu et al.
Cell adhesion & migration, 8(4), 396-403 (2014-12-09)
Amyloid precursor protein (APP), commonly associated with Alzheimer disease, is upregulated and distributes evenly along the injured axons, and therefore, also known as a marker of demyelinating axonal injury and axonal degeneration. However, the physiological distribution and function of APP
Nikki A McLean et al.
PloS one, 9(10), e110174-e110174 (2014-10-14)
Rapid and efficient axon remyelination aids in restoring strong electrochemical communication with end organs and in preventing axonal degeneration often observed in demyelinating neuropathies. The signals from axons that can trigger more effective remyelination in vivo are still being elucidated.

Numéro d'article de commerce international

RéférenceGTIN
MABN7704053252422553