HX0514
Hyaluronidase
Synonyme(s) :
Hyaluronidase
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Specific activity:
≥300 units/mg dry wt.
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conjugate (Glucosaminoglycan)
Quality Level
form
powder
specific activity
≥300 units/mg dry wt.
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
shipped in
ambient
storage temp.
−20°C
General description
300 units/mg minimum, 50,000 units/vial. Suitable for biochemistry grade.
Specifications:Activity: 300NF U/mg min
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
Specifications:Activity: 300NF U/mg min
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
Application
Hyaluronidase has been used:
- to enzymatically remove extra-cellular matrix (ECM) to assess the lateral diffusion of the synaptic a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR)
- to study the effects of 4-methylumbelliferone (4MU)/ hyaluronidase (HLX)-mediated depletion of the CD44/hyaluronan complex on trastuzumab binding in JIMT1 breast cancer xenografts
- as a component of Hank′s balanced salt solution (HBSS) medium to digest fetal intestine tissue
Biochem/physiol Actions
Hyaluronidase is an endoglycosidase that degrades hyaluronic acid (HA), a component of the extracellular matrix. It is used to enhance drug diffusion and reverse the effects of HA filler injections. Hyaluronidases dissolve the subcutaneous nodules and can correct excessive quantities of injected filler. It eliminates the cumulus-corona-oocyte complex formed during intracytoplasmic sperm injection. Hyaluronidase inhibits tissue damage after the extravasation of several substances. It is used for reducing edema treating vitreous hemorrhage.
Physical form
Dialyzed, lyophilized powder, not less than300 units per mg (dry weight).
Other Notes
One unit is based on the change in absorbency (turbidity) at 540 nm of an internal standard assayed concurrently with each lot. Internal standard replaces USP/NF reference no longer available.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificats d'analyse (COA)
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Articles
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Maurizio Cavallini et al.
Aesthetic surgery journal, 33(8), 1167-1174 (2013-11-08)
Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive
Sang Hak Lee et al.
eLife, 6 (2017-07-28)
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent
Patricia M R Pereira et al.
Molecular pharmaceutics, 17(1), 327-337 (2019-12-06)
Human epidermal growth factor receptor 2 (HER2) is a biomarker in breast cancer, and its overexpression is required to initiate therapies using HER2-targeted antibodies. Although trastuzumab is one of the most effective therapeutic antibodies in HER2-overexpressing breast cancer, a significant
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| HX0514-1 | 04055977230291 |