585970
(±)-Thalidomide
Selective inhibitor of TNF-α biosynthesis.
Synonyme(s) :
(±)-Thalidomide, (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
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A propos de cet article
Formule empirique (notation de Hill) :
C13H10N2O4
Numéro CAS:
Poids moléculaire :
258.23
UNSPSC Code:
12352200
MDL number:
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assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
InChI key
UEJJHQNACJXSKW-UHFFFAOYSA-N
General description
Selective inhibitor of TNFα biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.
Selective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.
Biochem/physiol Actions
Cell permeable: no
Primary Target
TNF-α biosynthesis
TNF-α biosynthesis
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Gershon, D. 1995. Nat. Med.1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
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Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 585970-100MG | 04055977265019 |