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A propos de cet article
Formule empirique (notation de Hill) :
C43H79N2O10P
Numéro CAS:
Poids moléculaire :
815.07
UNSPSC Code:
12352211
NACRES:
NA.25
Service technique
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Laissez-nous vous aiderNom du produit
17:0-20:4 PS, Avanti Research™ - A Croda Brand LM1302, methanol solution
form
methanol solution
packaging
pkg of 1 × 1 mL (LM1302-1EA)
manufacturer/tradename
Avanti Research™ - A Croda Brand LM1302
concentration
~10 μg/mL (Refer to C of A for lot specific concentration.)
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+]
InChI key
PVYYHCZONIFDMV-SPTHKXBTSA-N
General description
In humans, phosphoserine (PS) is present in the intracellular membranes and grey matter. It is localized to the nuclear envelope, endoplasmic reticulum, Golgi apparatus, outer mitochondrial membranes, plasma membranes and myelin.
Application
17:0-20:4 PS or 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine has been used as an internal standard:
- in lipid extraction from isolated pure mitochondria for mass spectrometry (MS) analysis
- for lipid quantification/analysis using liquid chromatography (LC)-MS
- for phospholipid quantification by MS
- in lysophospholipid acyltransferases (LPLAT) assay
- in the preparation of total lipid extracts from lysosome samples by tert-butyl methyl ether (MTBE) lipid extraction protocol for analysis by LC-MS
- for ratiometric quantification of phosphatidylserine (PS) using LC-MS
Biochem/physiol Actions
Phosphoserine (PS) maintains the nerve cell membrane and myelin sheath. It is found to be associated with cognitive disability in Alzheimer′s disease.
Packaging
2 mL Amber Glass Sealed Ampule (LM1302-1EA)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
Classe de stockage
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
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Di Ding et al.
Molecular neurobiology, 56(4), 2618-2639 (2018-07-28)
Neurons from the adult central nervous system (CNS) demonstrate limited mRNA transport and localized protein synthesis versus developing neurons, correlating with lower regenerative capacity. We found that deimination (posttranslational conversion of protein-bound arginine into citrulline) undergoes upregulation during early neuronal
Penelope Dimas et al.
eLife, 8 (2019-05-08)
Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by depleting FA synthase (FASN) from OL
Ulrike Bruning et al.
Cell metabolism, 28(6), 866-880 (2018-08-28)
The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely characterized. We report that fatty acid synthase knockdown (FASNKD) in ECs impedes vessel sprouting by reducing proliferation. Endothelial loss of FASN impaired angiogenesis in vivo, while FASN blockade reduced
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| LM1302-1EA | 04061837669675 |