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890890C

Avanti

18:1 TAP (DOTAP)

Avanti Research™ - A Croda Brand

Synonyme(s) :

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

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A propos de cet article

Formule empirique (notation de Hill) :
C42H80NO4Cl
Numéro CAS:
132172-61-3
Poids moléculaire :
698.54
MDL number:
MFCD01310872
UNSPSC Code:
12352211
NACRES:
NA.25
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assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (890890C-25mg), pkg of 2 × 20 mL (890890C-1g), pkg of 2 × 4 mL (890890C-200mg), pkg of 5 × 4 mL (890890C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (890890C-25mg), 25 mg/mL (890890C-1g), 25 mg/mL (890890C-200mg), 25 mg/mL (890890C-500mg)

application(s)

advanced drug delivery

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

InChI

1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

InChI key

KSXTUUUQYQYKCR-LQDDAWAPSA-M

Application

18:1 TAP (DOTAP) has been used in the preparation of liposome-supported bilayers.

Biochem/physiol Actions

18:1 TAP (DOTAP) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP(1,2-dioleoyl-3-trimethylammonium-propane). 18:1 TAP (DOTAP) mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (890890C-1g)
5 mL Clear Glass Sealed Ampule (890890C-200mg)
5 mL Clear Glass Sealed Ampule (890890C-25mg)
5 mL Clear Glass Sealed Ampule (890890C-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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Consulter la Bibliothèque de documents

Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
Dengler EC, et al.
J. Controlled Release, 168(2), 209-224 (2013)
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
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Numéro d'article de commerce international

RéférenceGTIN
890890C-25MG04061837668982
890890C-1G04061837668968
890890C-200MG04061837668975
890890C-500MG04061837668999