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860065P

Avanti

Ganglioside GM1 (Ovine Brain)

Avanti Research™ - A Croda Brand

Synonyme(s) :

110952

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A propos de cet article

Numéro CAS:
37758-47-7
MDL number:
MFCD00466936
UNSPSC Code:
12352211
NACRES:
NA.25
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description

GM1 Ganglioside (Brain, Ovine-Sodium Salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860065P-1mg), pkg of 1 × 10 mg (860065P-10mg), pkg of 1 × 25 mg (860065P-25mg), pkg of 1 × 5 mg (860065P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O[C@@H]4O[C@H](CO)[C@@H]([C@H](O[C@@H]5O[C@H

InChI

1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1

InChI key

CNLVNZJJSHZYAS-ALSOZVJRSA-N

General description

Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain. Ganglioside GM1 has five glycosyl units.

Application

Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies. It has also been used in liposome preparation for circular dichroism studies with human wild type−synuclein. It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis.

Biochem/physiol Actions

Ganglioside GM1 is a modulator of Ca2+ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.

Packaging

5 mL Amber Glass Screw Cap Vial (860065P-10mg)
5 mL Amber Glass Screw Cap Vial (860065P-1mg)
5 mL Amber Glass Screw Cap Vial (860065P-25mg)
5 mL Amber Glass Screw Cap Vial (860065P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Combination of ESI and MALDI mass spectrometry for qualitative, semi-quantitative and in situ analysis of gangliosides in brain
Zhang Y, et al.
Scientific reports, 6(, 25289-25289 (2016)
Tyuji Hoshino et al.
The journal of physical chemistry. B, 117(27), 8085-8094 (2013-05-22)
Accumulation and fibril formation of amyloid β (Aβ) peptides onto a ganglioside-rich lipid membrane is a cause of neuro-disturbance diseases. To find out a measure for suppressing the nucleation of a seed for amyloid fibrils, the mechanism of the initial
The multi-tasked life of GM1 ganglioside, a true factotum of nature
Ledeen RW and Wu G
Trends in Biochemical Sciences, 40(7), 407-418 (2015)
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Numéro d'article de commerce international

RéférenceGTIN
860065P-10MG04061835316878
860065P-5MG04061835316908
860065P-1MG04061835316885
860065P-25MG04061835316892