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A propos de cet article
Formule empirique (notation de Hill) :
C81H148O17P2Na2
Numéro CAS:
Poids moléculaire :
1501.96
MDL number:
NACRES:
NA.25
UNSPSC Code:
51191904
Service technique
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Laissez-nous vous aiderdescription
1′,3′-bis[1,2-dioleoyl-sn-glycero-3-phospho]-glycerol (sodium salt), chloroform
assay
>99% (TLC)
form
solution
packaging
pkg of 1 × 2.5 mL (710335C-25mg), pkg of 2 × 4 mL (710335C-200mg), pkg of 5 × 4 mL (710335C-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
10 mg/mL (710335C-25mg), 25 mg/mL (710335C-200mg), 25 mg/mL (710335C-500mg)
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
General description
Cardiolipin has two phosphatidyl residues linked by glycerol. 18:1 Cardiolipin or tetraoleoyl cardiolipin (TOCL) is a monounsaturated phospholipid present in mitochondria. TOCL bilayers have a larger hydrocarbon chain thickness compared to dioleoyl phosphatidylcholine (DOPC) bilayer.
Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane, which makes up to 20% of total lipids. Cardiolipin is a non-bilayer anionic phospholipid, which possesses four acyl chains and a small headgroup.
Cardiolipin is an anionic phospholipid.
Application
18:1 Cardiolipin has been used as a lipid standard in radiolabeling assay.
18:1 Cardiolipin has been used for preparing solubilized lipids to assemble nanodiscs.
18:1 Cardiolipin has been used:
- in liposome preparation for reconstituting yeast AAA ATPase protein, Msp1
- in in vitro translation system for RNA transfection
- as a synthetic lipid component to mimic mitochondrial inner membrane
Biochem/physiol Actions
Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.
Cardiolipin is involved in the dynamic organization of membranes and in cell division. It modulates the proton uptake pathway. Cardiolipin plays a critical role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It controls cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.
Cardiolipin participates in proton uptake pathway and also maintains the structure of enzymes involved. Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.
Packaging
5 mL Clear Glass Sealed Ampule (710335C-200mg)
5 mL Clear Glass Sealed Ampule (710335C-25mg)
5 mL Clear Glass Sealed Ampule (710335C-500mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
Classe de stockage
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
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Contenu apparenté
Phosphatidylglycerophosphate phosphatase is required for root growth in Arabidopsis
Lin YC, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(6), 563-575 (2018)
The role of cardiolipin in cardiovascular health
Shen Z, et al.
BioMed Research International, 2015 (2015)
Reconstitution of Mitochondrial Membrane Proteins into Nanodiscs by Cell-Free Expression
Malhotra K and Alder NN
Methods in Molecular Biology, 155-178 (2017)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 710335C-200MG | 04061837790980 |
| 710335C-25MG | 04061837790997 |
| 710335C-500MG | 04061837791000 |