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907316

GlcA-ABP

Name: GlcA-ABP
Brand: ALDRICH

95%

Synonyme(s) :

(2S,3S,4S,5R,6S)-6-(2-(difluoromethyl)-4-(hex-5-ynamido)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid, Glucuronic acid activity-based probe, Glucuronidated metabolite mimic

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₉H₂₁F₂NO₈

Poids moléculaire :

429.37

UNSPSC Code:

12352101

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Propriétés

assay

95%

form

solid

storage temp.

−20°C

Description

Application

This glucuronic acid activity-based probe (GlcA-ABP) is a glucuronidated metabolite mimic that provides in situ detection of active β-glucuronidases in the gut microbiome. The probe reacts with nucleophilic residues of the target, and the alkyne tag enables subsequent bioorthogonal tagging via click chemistry for enrichment (i.e. biotin tags) or imaging and cell sorting (i.e. fluorescent tags). With GlcA-ABP, Whidbey, et al were able to pair the activity-based probe (ABP) with fluorescence-activated cell sorting (FACS; ABP-FACS) to identify β-glucuronidase-active taxa in the gut microbiota.

Currently in gut microbiome research, access to and differentiation between subpopulations and their relationships to host biochemistry is a challenge. Functional and chemical approaches such as those with GlcA-ABP provide a complementary tool to gene sequencing.

Other Notes

A Probe-Enabled Approach for the Selective Isolation and Characterization of Functionally Active Sub populations in the Gut Microbiome

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A Probe-Enabled Approach for the Selective Isolation and Characterization of Functionally Active Subpopulations in the Gut Microbiome.

Christopher Whidbey et al.

Journal of the American Chemical Society (2018-12-14)

Commensal microorganisms in the mammalian gut play important roles in host health and physiology, but a central challenge remains in achieving a de-tailed mechanistic understanding of specific microbial contributions to host biochemistry. New function-based approaches are needed that analyze gut

Numéro d'article de commerce international

Référence	GTIN
907316-10MG	04022536043531