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903027

QPhos Pd G3

powder

Synonyme(s) :

QPhos G3 Palladacycle, QPhos Palladacycle, [2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][1′-[bis(1,1-dimethylethyl)phosphino]-1,2,3,4,5-pentaphenylferrocene](methanesulfonato-κO)palladium

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A propos de cet article

Formule empirique (notation de Hill) :
C61H60FeNO3PPdS
Numéro CAS:
2021255-91-2
Poids moléculaire :
1080.44
NACRES:
NA.22
UNSPSC Code:
12161600
MDL number:
MFCD12911997
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Nom du produit

QPhos Pd G3,

product line

Buchwald precatalyst Generation 3

form

powder

feature

generation 3

reaction suitability

core: palladium, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst
reaction type: Cross Couplings

functional group

phosphine

SMILES string

O=S(=O)([O-][Pd+2]1([C-]=2C=CC=CC2C=3C=CC=CC3[NH2]1)[P](C(C)(C)C)(C(C)(C)C)[C-]45[CH]6=[CH]7[CH]8=[CH]4[Fe+2]7869%10%11%125C=%13(C=%14C=CC=CC%14)C%12(C=%15C=CC=CC%15)=C%11(C=%16C=CC=CC%16)[C-]%10(C=%17C=CC=CC%17)C%139C=%18C=CC=CC%18)C

InChI

InChI=1S/C35H25.C13H22P.C12H10N.CH4O3S.Fe.Pd/c1-6-16-26(17-7-1)31-32(27-18-8-2-9-19-27)34(29-22-12-4-13-23-29)35(30-24-14-5-15-25-30)33(31)28-20-10-3-11-21-28;1-12(2,3)14(13(4,5)6)11-9-7-8-10-11;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;;/h1-25H;7-10H,1-6H3;1-6,8-9H,13H2;1H3,(H,2,3,4);;/q3*-1;;2*+2/p-1

InChI key

NNVAEYGNFLUPRU-UHFFFAOYSA-M

General description

QPhos Pd G3 is a third generation (G3) Buchwald precatalyst. It is air, moisture and thermally-stable and is highly soluble in a wide range of common organic solvents. It has long life in solutions. QPhos Pd G3 is an excellent reagent for palladium catalyzed cross-coupling reactions. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

Application

QPhos Pd G3 has been used as a precatalyst for the arylboration of isoprene with regioselectivity. It may also be used for a variety of aminination and etherifications of aryl halides.

Other Notes

Technology Spotlight: G3 and G4 Buchwald Precatalysts

Regioselective Arylboration of Isoprene and Its Derivatives by Pd/Cu Cooperative Catalysis

Synthesis of Complex Drug like Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents

Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

G3 and G4 Buchwald Precatalysts

G3 and G4 Buchwald palladium precatalysts are the newest air, moisture, and thermally stable crossing-coupling complexes used in bond formation for their versatility and high reactivity.

AdQPhos and Pd pre catalysts for alpha arylation reaction

Discover AdQPhos and its Pd pre-catalysts for selective α-arylation of diverse nucleophiles under mild aqueous conditions without hazardous solvents.

Kevin B Smith et al.
Journal of the American Chemical Society, 139(23), 7721-7724 (2017-06-06)
A method for the regioselective arylboration of isoprene and its derivatives is presented. These reactions allow for the synthesis of useful building blocks from simple components. Through these studies, an unusual additive effect with DMAP has been uncovered that allows
Thomas J Greshock et al.
Angewandte Chemie (International ed. in English), 55(44), 13714-13718 (2016-10-22)
The reactivity of a representative set of 17 organozinc pivalates with 18 polyfunctional druglike electrophiles (informers) in Negishi cross-coupling reactions was evaluated by high-throughput experimentation protocols. The high-fidelity scaleup of successful reactions in parallel enabled the isolation of sufficient material