900615
(4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone
≥95%
Synonyme(s) :
Hydroxyl benzophenone alkyne, Probe building block
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A propos de cet article
Formule empirique (notation de Hill) :
C16H12O3
Numéro CAS:
Poids moléculaire :
252.26
UNSPSC Code:
12352200
NACRES:
NA.22
MDL number:
Assay:
≥95%
Form:
solid
Service technique
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Laissez-nous vous aiderQuality Level
assay
≥95%
form
solid
reaction suitability
reaction type: click chemistry
storage temp.
−20°C
SMILES string
O(CC#C)c1ccc(cc1)C(=O)c2ccc(cc2)O
InChI
1S/C16H12O3/c1-2-11-19-15-9-5-13(6-10-15)16(18)12-3-7-14(17)8-4-12/h1,3-10,17H,11H2
InChI key
TZKIHDJSIXVMIQ-UHFFFAOYSA-N
Application
(4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Other Notes
Technology Spotlight: Trifuctional Probe Building Blocks
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS
Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids
Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators
γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| C9373-25MG | 04061832897738 |
| C9373-5MG | 04061832897745 |
| 900615-100MG | 04061833250556 |