367532
5-Chloro-1-methyl-4-nitroimidazole
98%
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A propos de cet article
Formule empirique (notation de Hill) :
C4H4ClN3O2
Numéro CAS:
Poids moléculaire :
161.55
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
225-521-2
MDL number:
Assay:
98%
Service technique
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Laissez-nous vous aiderQuality Level
assay
98%
mp
148-150 °C (lit.)
functional group
chloro, nitro
SMILES string
Cn1cnc(c1Cl)[N+]([O-])=O
InChI
1S/C4H4ClN3O2/c1-7-2-6-4(3(7)5)8(9)10/h2H,1H3
InChI key
OSJUNMSWBBOTQU-UHFFFAOYSA-N
General description
5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.
Application
5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole.
M E Watts et al.
International journal of radiation biology and related studies in physics, chemistry, and medicine, 38(6), 673-675 (1980-12-01)
M E Watts et al.
International journal of radiation oncology, biology, physics, 12(7), 1135-1138 (1986-07-01)
The "extra" radiosensitization seen with GSH-reactive nitro compounds is too large to be accounted for by GSH-depletion acting independently--there must be competition. The GS-conjugate leaks out of cells slowly and is trapped at high concentrations. Its properties, such as concentration
The effect of electron-affinic radiosensitizers on ATP levels in V79 379A Chinese hamster cells.
R J Hodgkiss
Biochemical pharmacology, 36(3), 393-396 (1987-02-01)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 367532-5G | 04061831827378 |