PSMC5
proteasome (prosome, macropain) 26S subunit, ATPase, 5
Synonyms:
S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG
Species:
Human PSMC5 (5705), Mouse Psmc5 (19184), Rat Psmc5 (81827), cow PSMC5 (282015), sheep PSMC5 (101104076), naked mole-rat Psmc5 (101710432), domestic guinea pig Psmc5 (100717173), Zebrafish psmc5 (445285), chicken PSMC5 (428274), Horse PSMC5 (100053987) ...More
UniProtKB ID:
Gene ID:
- Human(5705) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
- Mouse(19184) protease (prosome, macropain) 26S subunit, ATPase 5
- Rat(81827) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- cow(282015) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- sheep(101104076) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- naked mole-rat(101710432) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- domestic guinea pig(100717173) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- Zebrafish(445285) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- chicken(428274) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- Horse(100053987) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- domestic cat(101097360) proteasome (prosome, macropain) 26S subunit, ATPase, 5
- dog(480478) proteasome (prosome, macropain) 26S subunit, ATPase, 5
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PSMC5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PSMC5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry