X4002
Xanthine
≥99%, synthetic (organic), powder
Synonym(s):
2,6-Dihydroxypurine
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About This Item
Empirical Formula (Hill Notation):
C5H4N4O2
CAS Number:
Molecular Weight:
152.11
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-718-6
MDL number:
Beilstein/REAXYS Number:
8733
Assay:
≥99%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
1 M NaOH: 0.1 M, clear, colorless to light yellow
Product Name
Xanthine, BioUltra, ≥99%
biological source
synthetic (organic)
Quality Level
product line
BioUltra
assay
≥99%
form
powder
impurities
≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter
ign. residue
≤0.1%
solubility
1 M NaOH: 0.1 M, clear, colorless to light yellow
anion traces
sulfate (SO42-): <0.05%
cation traces
Al: ≤0.0005%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%
SMILES string
O=C1NC(=O)c2nc[nH]c2N1
InChI
1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)
InChI key
LRFVTYWOQMYALW-UHFFFAOYSA-N
General description
Xanthine is a purine that can be produced in the purine metabolic pathway via different precursors:
- Guanine deamination by guanine deaminase
- Hypoxanthine conversion by xanthine oxidoreductase
Xanthine or its derivatives are naturally present in animal organs, yeast, potatoes, coffee beans, and tea.
Application
Xanthine has been used as a substrate for the determination of xanthine oxidase (XOD) inhibitory activity. It has also been used in the following systems:
- yeast culture
- human cell line culture
- recombinant viruses cloned as bacterial artificial chromosomes in Escherichia coli
Biochem/physiol Actions
Xanthine and xanthine oxidase are used to generate superoxide radicals to measure the activity of superoxide dismutase.
Features and Benefits
- Tested for trace metal content (fuller details in Properties section and on Specification Sheet)
- Tested for trace sulfate content (fuller details in Properties section and on Specification Sheet)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Instructions
Gavin C Higgins et al.
Free radical biology & medicine, 53(10), 1960-1967 (2012-09-18)
Neurons can undergo a diverse range of death responses under oxidative stress, encompassing apoptosis (caspase-dependent, programmed cell death) to various forms of caspase-independent death, including necrosis. We recently showed that primary murine cortical neurons exposed acutely to hydrogen peroxide undergo
Sergey Dikalov et al.
Biochemical pharmacology, 76(5), 589-596 (2008-07-22)
Honokiol, a compound extracted from Magnolia officinalis, has antitumor and antiangiogenic properties in several tumor models in vivo. Among the downstream pathways inhibited by honokiol is nuclear factor kappa beta (NFkappabeta). A prime physiologic stimulus of NFkappabeta is reactive oxygen
R Hille et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 9(11), 995-1003 (1995-08-01)
Xanthine oxidase and xanthine dehydrogenase are enzymes involved in the metabolism of purines and pyrimidines in various organisms. Their relationship to one another has been the subject of considerable debate, primarily because of their proposed roles in ischemia/reperfusion damage in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| X4002-1G | 04061837549663 |
| X4002-25G | 04061833632727 |
| X4002-5G | 04061837549670 |