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P4394

cis-Diammineplatinum(II) dichloride

Name: <I>cis</I>-Diammineplatinum(II) dichloride
Brand: SIGMA

≥99.99% (trace metal analysis), crystalline, macrophage activator

Synonym(s):

cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin

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About This Item

Linear Formula:

Pt(NH₃)₂Cl₂

CAS Number:

15663-27-1

Molecular Weight:

300.05

NACRES:

NA.77

PubChem Substance ID:

24278632

UNSPSC Code:

12352200

EC Number:

239-733-8

MDL number:

MFCD00011623

Form:

crystalline

Quality level:

200

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Properties

Product Name

cis-Diammineplatinum(II) dichloride, crystalline

form

crystalline

Quality Level

200

color

yellow

mp

270 °C (lit.)

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

originator

Corden

SMILES string

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key

LXZZYRPGZAFOLE-UHFFFAOYSA-L

Description

Application

cis-Diammineplatinum(II) dichloride has been used:

in cell viability measurement in cochlear explants
in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma

Biochem/physiol Actions

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca²⁺/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information.