L0649
Leupeptin hydrochloride
powder, ≥70% (HPLC)
Synonym(s):
Acetyl-Leu-Leu-Arg-al hydrochloride
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C20H38N6O4 · HCl
CAS Number:
Molecular Weight:
463.01
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Leupeptin hydrochloride, microbial, ≥70% (HPLC)
biological source
microbial
Quality Level
assay
≥70% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to yellow
storage temp.
−20°C
SMILES string
Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
InChI
1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
InChI key
OQQYPQNFLLAILR-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
Analysis Note
Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.
Still not finding the right product?
Explore all of our products under Leupeptin hydrochloride
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Related Content
Determination of ERK activity: antiphospho-ERK antibodies, in vitro phosphorylation, and in-gel kinase assay.
Sarah Kraus et al.
Methods in molecular biology (Clifton, N.J.), 250, 29-48 (2004-02-03)
Suzanne Elsasser et al.
Methods in molecular biology (Clifton, N.J.), 832, 403-422 (2012-02-22)
The proteasome is an ATP-dependent molecular machine that degrades proteins through the concerted activity of dozens of subunits. It is the yin to the ribosome's yang, and together these entities mold the protein landscape of the cell. Native gels are
Shanti Pal Gangwar et al.
STAR protocols, 2(4), 100855-100855 (2021-10-15)
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that play crucial roles in the central nervous system. iGluR homologs, termed glutamate receptor-like channels (GLRs), have been found in plants. Investigating the structural and functional relationship between iGluRs and GLRs was
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L0649-100MG | 04061833262986 |
| L0649-25MG | 04061833948910 |
| L0649-5MG | 04061833948927 |