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D201863

1,4-Dioxane

ReagentPlus®, ≥99%, contains ≤25 ppm BHT as stabilizer

Synonym(s):

Diethylene oxide, Dioxane

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About This Item

Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
Molecular Weight:
88.11
UNSPSC Code:
12352005
NACRES:
NA.21
PubChem Substance ID:
EC Number:
204-661-8
Beilstein/REAXYS Number:
102551
MDL number:
Assay:
≥99%
Technique(s):
thin layer chromatography (TLC): suitable
Bp:
100-102 °C (lit.)
Vapor pressure:
27 mmHg ( 20 °C), 40 mmHg ( 25 °C)
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vapor density

3 (vs air)

Quality Level

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

product line

ReagentPlus®

assay

≥99%

form

liquid

autoignition temp.

356 °F

contains

≤25 ppm BHT as stabilizer

expl. lim.

22 %

technique(s)

thin layer chromatography (TLC): suitable

refractive index

n20/D 1.422 (lit.)

pH

6.0-8 (20 °C, 500 g/L)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

density

1.034 g/mL at 25 °C (lit.)

SMILES string

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

Application

1,4-Dioxane can be used as a solvent:
  • To synthesize 1,3-diamines and amino alcohols via 2-azaallyl anion benzylic ring-opening of aziridines.
  • In the RAFT polymerization of acryclic acid.
  • In the synthesis of cross-linked triblock copolymer hydrogels.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany


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signalword

Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup



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Articles

Discover AdQPhos and its Pd pre-catalysts for selective α-arylation of diverse nucleophiles under mild aqueous conditions without hazardous solvents.


High-toughness polycation cross-linked triblock copolymer hydrogels
Chen Y, et al.
Macromolecules, 50, 3637-3646 (2017)
Yimu Zhao et al.
Advanced healthcare materials, 8(5), e1801187-e1801187 (2019-02-10)
Due to escalating drug developmental costs and limitations of cardiotoxicity screening, there is an urgent need to develop robust in vitro 3D tissue culture platforms that can both facilitate the culture of human cardiac tissues and provide noninvasive functional readouts
Xiaohua Liu et al.
Biomaterials, 31(2), 259-269 (2009-09-29)
It remains a challenge to synthesize functional materials that can develop advanced scaffolding architectures for tissue engineering. In this study, a series of biodegradable amphiphilic poly(hydroxyalkyl (meth)acrylate)-graft-poly(l-lactic acid) (PHAA-g-PLLA) copolymers have been synthesized and fabricated into nano-fibrous scaffolds. These copolymers



Global Trade Item Number

SKUGTIN
D201863-18L-CS04061837717062
D201863-1L04061833561379
D201863-4L04061833561386