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Y0001456

Nitrendipine for peak identification

Name: Nitrendipine for peak identification
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Nitrendipine, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₀N₂O₆

CAS Number:

39562-70-4

Molecular Weight:

360.36

NACRES:

NA.24

PubChem Substance ID:

329831432

UNSPSC Code:

41116107

MDL number:

MFCD00082255

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Properties

grade

pharmaceutical primary standard

API family

nitrendipine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC

InChI

1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

InChI key

PVHUJELLJLJGLN-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nitrendipine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Effects of nitrendipine and other calcium antagonists on glucose metabolism in man.

B N Trost et al.

Journal of cardiovascular pharmacology, 6 Suppl 7, S986-S995 (1984-01-01)

Some calcium antagonists, including nitrendipine, were noted to cause a dose-dependent and reversible inhibition of insulin release in certain animal models. Therefore, it is important to know the effects of clinical treatment with calcium antagonists in nondiabetic or diabetic man.

Combination therapy of hypertension with beta-adrenoceptor blockers and the calcium channel antagonist nitrendipine.

E P Mac Carthy

Journal of cardiovascular pharmacology, 12 Suppl 4, S76-S79 (1988-01-01)

The combination of a beta-adrenoceptor-blocking drug with the dihydropyridine calcium channel antagonist, nitrendipine, has particular therapeutic advantages in the management of hypertension. The beta-blocker reduces any reflex increases in sympathetic nervous system and renin-angiotensin system activity that result from the

Review of long-term trials with nitrendipine.

U L Hulthén et al.

Journal of cardiovascular pharmacology, 12 Suppl 4, S11-S15 (1988-01-01)

The dihydropyridine calcium antagonist nitrendipine offers a pathophysiologically based antihypertensive treatment with a potent dilation of resistance vessels, increased arterial compliance, and an acute natriuretic/diuretic response. Prolonged nitrendipine treatment in essential hypertension is not associated with stimulation of the sympathetic

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Global Trade Item Number

SKU	GTIN
Y0001456	04061833797907