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B0301

Biotin

meets USP testing specifications

Synonym(s):

D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O3S
CAS Number:
58-85-5
Molecular Weight:
244.31
NACRES:
NA.21
PubChem Substance ID:
24891512
eCl@ss:
34058011
UNSPSC Code:
12352201
EC Number:
200-399-3
MDL number:
MFCD00005541
Beilstein/REAXYS Number:
86838
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biological source

synthetic (organic)

Quality Level

200

agency

meets USP testing specifications

assay

97.5-102.0%

form

powder

color

white

mp

231-233 °C (lit.)

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

SMILES string

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Application

<ul>
<li><strong>Protein Biotinylation Studies:</strong> Advanced strategies for biotinylation site characterization in proteins are being developed using biotin, improving the precision of protein modification techniques critical for biochemical research and drug development (Zhu, 2024).</li>
</ul>

Biochem/physiol Actions

Essential vitamin that is important for amino acid and energy metabolism, and fatty acid synthesis. It is a prosthetic group in four mammalian carboxylase families and facilitates the binding and transfer of carbon dioxide.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000296835
0000279250
0000296836
058K12141
037K13373

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Articles

Biotin in Cell Culture

Importance and uses of biotin in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

John J Tukker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(16), 6809-6825 (2013-04-19)
Hippocampal CA3 area generates temporally structured network activity such as sharp waves and gamma and theta oscillations. Parvalbumin-expressing basket cells, making GABAergic synapses onto cell bodies and proximal dendrites of pyramidal cells, control pyramidal cell activity and participate in network
Tuncay Baubec et al.
Cell, 153(2), 480-492 (2013-04-16)
To gain insight into the cellular readout of DNA methylation, we established a strategy for systematically profiling the genome-wide distribution of chromatin-interacting factors. This enabled us to create genomic maps for the methyl-CpG-binding domain (MBD) family of proteins, including disease-relevant
Tim J Viney et al.
Nature neuroscience, 16(12), 1802-1811 (2013-10-22)
Hippocampal sharp waves are population discharges initiated by an unknown mechanism in pyramidal cell networks of CA3. Axo-axonic cells (AACs) regulate action potential generation through GABAergic synapses on the axon initial segment. We found that CA3 AACs in anesthetized rats
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Global Trade Item Number

SKUGTIN
901112-100MG04061833259498
B0301-25G04061833419670
B0301-500MG04061833419687
B0301-5G04061833419694